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Redox-triggered intracellular siRNA delivery.
Abstract Gene silencing using small interfering RNA (siRNA) is a promising strategy for the treatment of multiple diseases. However, the low in vivo stability of siRNA, its poor pharmacokinetics and inability to penetrate inside cells limit its employment in the clinic. Here, we present a novel redox-sensitive micellar nanopreparation based on a triple conjugate of polyethylene glycol, polyethyleneimine and phosphatidylethanolamine, PEG-SS-PEI-PE (PSSPD). This non-toxic system efficiently condenses siRNA and specifically downregulates target green fluorescent protein (GFP) only under reducing conditions via intrac...
Source: Chemical Communications - June 5, 2018 Category: Chemistry Authors: Mutlu Agardan NB, Sarisozen C, Torchilin VP Tags: Chem Commun (Camb) Source Type: research

Coumarin Containing Star Shaped 4-arm Polyethylene glycol (PEG): Targeted Fluorescent Organic Nanoparticles for efficient dual treatment of Photodynamic therapy (PDT) and Chemotherapy
Photochem. Photobiol. Sci., 2015, Accepted ManuscriptDOI: 10.1039/C5PP00057B, PaperMoumita Gangopadhyay, Tanya Singh, Krishna Kalyani Behara, Surendra Karwa, Sudip Ghosh, Pradeep N.D. SinghSingle component fluorescent organic polymeric nanoparticles (NPs) has been synthesized based on a star shaped 4-arm PEG containing coumarin chromophore for concomitant employment of Photodynamic therapy (PDT) and chemotherapy synergistically...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Photochem. Photobiol. Sci. latest articles - May 26, 2015 Category: Chemistry Authors: Moumita Gangopadhyay Source Type: research