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Drug: Polyethylene Glycol
Management: European Medicines Agency (EMA)

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Pharmacotherapies that specifically target ammonia for the prevention and treatment of hepatic encephalopathy in adults with cirrhosis.
CONCLUSIONS: There is insufficient evidence to determine the effects of these pharmacotherapies on the prevention and treatment of hepatic encephalopathy in adults with cirrhosis. They have the potential to reduce blood ammonia concentrations when compared to placebo, but their overall effects on clinical outcomes of interest and the potential harms associated with their use remain uncertain. Further evidence is needed to evaluate the potential beneficial and harmful effects of these pharmacotherapies in this clinical setting. PMID: 31204790 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 16, 2019 Category: General Medicine Authors: Zacharias HD, Zacharias AP, Gluud LL, Morgan MY Tags: Cochrane Database Syst Rev Source Type: research