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Source: Biomacromolecules
Drug: Polyethylene Glycol
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Total 64 results found since Jan 2013.
Lysozyme-Immobilized Polyethersulfone Membranes with Satisfactory Hemocompatibility and High Enzyme Activity for Endotoxin Removal
In this study, we propose a new approach for developing the functional polyethersulfone (PES) membrane to remove endotoxins. First, the PES polymer is grafted with polyethylene glycol methyl acrylate (PEG-MA) in a homogeneous phase system via γ irradiation, and PES-g-PEG can be directly used to prepare the membrane by the phase inversion method. Then, polydopamine (PDA) is coated as an adhesive layer onto a PES-g-PEG membrane in an alkaline aqueous solution, and lysozyme (Lyz) is covalently immobilized with PDA through the Schiff base reaction. Lysozyme acts as an affinity adsorption ligand of endotoxin through charge and...
Source: Biomacromolecules - August 18, 2023 Category: Biochemistry Authors: Jingxia Wang Chaorong Peng Xijing Yang Maojun Ni Xiaobin Zhang Zhenqiang Shi Hao Chen Siyang Liu Lunqiang Jin Changsheng Zhao Source Type: research
Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery
Biomacromolecules. 2023 Jun 12. doi: 10.1021/acs.biomac.3c00265. Online ahead of print.ABSTRACTProtease-responsive multi-arm polyethylene glycol-based microparticles with biscysteine peptide crosslinkers (CGPGG↓LAGGC) were obtained for intradermal drug delivery through inverse suspension photopolymerization. The average size of the spherical hydrated microparticles was ∼40 μm after crosslinking, making them attractive as a skin depot and suitable for intradermal injections, as they are readily dispensable through 27G needles. The effects of exposure to matrix metalloproteinase 9 (MMP-9) on the microparticles were eval...
Source: Biomacromolecules - June 12, 2023 Category: Biochemistry Authors: Heidi K Noddeland Marianne Lind Karsten Petersson Frank Caruso Martin Malmsten Andrea Heinz Source Type: research
Diffusion NMR and Rheology of a Model Polymer in Bacterial Cell Lysate Crowders
Biomacromolecules. 2023 May 22. doi: 10.1021/acs.biomac.2c01534. Online ahead of print.ABSTRACTThe intracellular milieu is crowded and heterogeneous, and this can have profound consequences for biomolecule motions and biochemical kinetics. Macromolecular crowding has been traditionally studied in artificial crowders like Ficoll and dextran or globular proteins such as bovine serum albumin. It is, however, not clear if the effects of artificial crowders on such phenomena are the same as the crowding that is experienced in a heterogeneous biological environment. Bacterial cells, for example, are composed of heterogeneous bio...
Source: Biomacromolecules - May 22, 2023 Category: Biochemistry Authors: Yanitza Trosel Liam P Gregory Valerie K Booth Anand Yethiraj Source Type: research
Tuning Targeted Liposome Avidity to Cells via Lipid Phase Separation
Biomacromolecules. 2023 Mar 21. doi: 10.1021/acs.biomac.2c01338. Online ahead of print.ABSTRACTThe addition of both cell-targeting moieties and polyethylene glycol (PEG) to nanoparticle (NP) drug delivery systems is a standard approach to improve the biodistribution, specificity, and uptake of therapeutic cargo. The spatial presentation of these molecules affects avidity of the NP to target cells in part through an interplay between the local ligand concentration and the steric hindrance imposed by PEG molecules. Here, we show that lipid phase separation in nanoparticles can modulate liposome avidity by changing the proxim...
Source: Biomacromolecules - March 21, 2023 Category: Biochemistry Authors: Timothy Q Vu Lucas E Sant'Anna Neha P Kamat Source Type: research
Highly Prolonged Release of the Cancer Vaccine and Immunomodulator via a Two-Layer Biodegradable Microneedle for Prophylactic Treatment of Metastatic Cancer
Biomacromolecules. 2023 Feb 21. doi: 10.1021/acs.biomac.2c01270. Online ahead of print.ABSTRACTSimultaneous sustained release of cancer vaccines and immunomodulators may effectively trigger durable immune responses and avoid multiple administrations. Here, we established a biodegradable microneedle (bMN) based on a biodegradable copolymer matrix made of polyethylene glycol (PEG) and poly(sulfamethazine ester urethane) (PSMEU). This bMN was applied to the skin and slowly degraded in the epidermis/dermis layers. Then, the complexes composed of a positively charged polymer (DA3), cancer DNA vaccine (pOVA), and toll-like recep...
Source: Biomacromolecules - February 21, 2023 Category: Biochemistry Authors: Huu Thuy Trang Duong Yue Yin Thai Minh Duy Le Ji Hoon Jeong Doo Sung Lee Source Type: research
Adjusting Degree of Modification and Composition of gelAGE-Based Hydrogels Improves Long-Term Survival and Function of Primary Human Fibroblasts and Endothelial Cells in 3D Cultures
This study aimed to develop a suitable hydrogel-based 3D platform to support long-term culture of primary endothelial cells (ECs) and fibroblasts. Two hydrogel systems based on allyl-modified gelatin (gelAGE), G1MM and G2LH, were cross-linked via thiol-ene click reaction with a four-arm thiolated polyethylene glycol (PEG-4-SH). Compared to G1MM, the G2LH hydrogel was characterized by the lower polymer content and cross-linking density with a softer matrix and homogeneous and open porosity. Cell viability in both hydrogels was comparable, although the G2LH-based platform supported better F-actin organization, cell-cell inte...
Source: Biomacromolecules - February 14, 2023 Category: Biochemistry Authors: Hatice Gen ç Alessandro Cianciosi Raphael Lohse Philipp Stahlhut J ürgen Groll Christoph Alexiou Iwona Cicha Tomasz J üngst Source Type: research
Multicolor Light-Induced Immune Activation via Polymer Photocaged Cytokines
Biomacromolecules. 2023 Feb 6. doi: 10.1021/acs.biomac.2c01207. Online ahead of print.ABSTRACTCytokines act as potent, extracellular signals of the human immune system and can elicit striking treatment responses in patients with autoimmune disease, tissue damage, and cancer. Yet, despite their therapeutic potential, recombinant cytokine-mediated immune responses remain difficult to control as their administration is often systemic, whereas their intended sites of action are localized. To address the challenge of spatially and temporally constraining cytokine signals, we recently devised a strategy whereby recombinant cytok...
Source: Biomacromolecules - February 6, 2023 Category: Biochemistry Authors: Lacey A Birnbaum Emily C Sullivan Priscilla Do Biaggio Uricoli Sunil S Raikar Christopher C Porter Curtis J Henry Erik C Dreaden Source Type: research
Synthesis and Characterization of Amino-Functional Polyester Dendrimers Based On Bis-MPA with Enhanced Hydrolytic Stability and Inherent Antibacterial Properties
In this study, we present a new generation of amine functional bis-MPA polyester dendrimers with increased hydrolytic stability as well as antibacterial activity for Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) planktonic bacteria strains. These new derivatives show generally good cytocompatibility for the concentrations they are active toward bacteria, in monocyte/macrophage-like cells (Raw 264.7), and human dermal fibroblasts. Fluoride - promoted esterification chemistry, anhydride chemistry, and click reactions were utilized to pr...
Source: Biomacromolecules - January 23, 2023 Category: Biochemistry Authors: Faridah Namata Natalia Sanz Del Olmo Noemi Molina Michael Malkoch Source Type: research
