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Source: Cell Research
Drug: Polyethylene Glycol
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Total 43 results found since Jan 2013.
Sustained neurotrophin-3 delivery from hyaluronic acid hydrogels for neural tissue regeneration
J Biomed Mater Res A. 2023 Sep 7. doi: 10.1002/jbm.a.37596. Online ahead of print.ABSTRACTThe goal of this work was to design a polymer-based platform capable of localized, long-term delivery of biologically active neurotropic factors using an affinity-based approach. Here, we synthesized hyaluronic acid-methylfuran (HA-mF) hydrogels that provide sustained, affinity-based release of neurotrophin-3 (NT-3), a growth factor that promotes axon growth for 28 days. A Diels-Alder crosslinking reaction between HA-mF and polyethylene glycol (PEG)-dimaleimide occurs within 15 min under physiological conditions, resulting in hydrogel...
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Pablo Ramos Ferrer Sangamithra Vardhan Shelly Sakiyama-Elbert Source Type: research
Ultrasound-mediated multifunctional magnetic microbubbles for drug delivery of celastrol in VX2 liver transplant tumors
Drug Deliv Transl Res. 2023 Aug 28. doi: 10.1007/s13346-023-01421-9. Online ahead of print.ABSTRACTCelastrol (CST) has positive pharmacological effects on various cancers, but clinical application is limited because of poor water solubility and systemic toxicity. Ferric oxide (Fe3O4) has a large specific surface area and can be functionalized by inorganic modification to form complex magnetic drug delivery systems. Herein, Fe3O4 was surface-modified with citric acid and polyethylene glycol (PEG) (via) the Mitsunobu reaction and then covalently bound to CST. Finally, magnetic microbubbles (MMBs) containing perfluoropropane ...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Jian Huang Zhengji Wang Zihe Chen Chunxin Huang Ying Wang Xing Li Weiyang Lv Guiqiang Qi Huilin Liu Source Type: research
Efficient delivery of mesenchymal stem/stromal cells to injured liver by surface PEGylation
CONCLUSION: These results indicate that PEG modification to the surface of MSCs can suppress the lung entrapment of intravenously administered MSCs and improve their homing to the injured liver.PMID:37608303 | DOI:10.1186/s13287-023-03446-w
Source: Cell Research - August 23, 2023 Category: Cytology Authors: Yukiya Takayama Kosuke Kusamori Yuri Katsurada Shu Obana Shoko Itakura Makiya Nishikawa Source Type: research
PEGylated Fluorescent Anti-Carcinoembryonic Antigen Antibody Labels Colorectal Cancer Tumors in Orthotopic Mouse Models
CONCLUSIONS: M5A-IR800-SW provided bright and targeted NIR images of human CRC in orthotopic primary-tumor and liver-metastasis mouse models. The results of the present study suggest the clinical potential of M5A-IR800-SW for fluorescence-guided surgery including metastasectomies for CRC. The lack of hepatic NIR signal is of critical importance to allow for precise labeling of liver tumors.PMID:37540977 | DOI:10.1016/j.jss.2023.06.013
Source: Cell Research - August 4, 2023 Category: Cytology Authors: Michael A Turner Siamak Amirfakhri Hiroto Nishino Nicholas C Neel Mojgan Hosseini Kristin E Cox Thinzar M Lwin Lin Li Teresa Hong Anakim Sherman John E Shively Robert M Hoffman Paul J Yazaki Michael Bouvet Source Type: research
Study on Contrast-Enhanced Ultrasound Imaging and Anti-Tumor Effects of Drug-Loaded Nanodroplets with Tumor Targeting and Ultrasound Sensitivity
CONCLUSIONS: The FA-NDs/DOX prepared in this study has excellent performance in contrast-enhanced ultrasound imaging, tumor targeting and enhanced chemotherapy. This FA-NDs/DOX with polymer shells provides a novel platform for ultrasound molecular imaging and tumor therapy.PMID:37395016 | DOI:10.31083/j.fbl2806115
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Yaqiong Li Yongqing Chen Ruiqing Liu Shaobo Duan Lijuan Chen Jun Sun Lianzhong Zhang Source Type: research
A novel combination therapy of arginine deiminase and an arginase inhibitor targeting arginine metabolism in the tumor and immune microenvironment
This study implied the possibility of L-Norvaline as a modulator of the immune response in cancer and provided a new potential therapy combined with ADI-PEG 20.PMID:37293150 | PMC:PMC10244097
Source: Cell Research - June 9, 2023 Category: Cytology Authors: Pei-Hsuan Ye Chung-Yen Li Hao-Yu Cheng Gangga Anuraga Chih-Yang Wang Feng-Wei Chen Shiang-Jie Yang Kuo-Ting Lee Kwang-Yu Chang Ming-Derg Lai Source Type: research
Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions
Drug Deliv Transl Res. 2023 May 6. doi: 10.1007/s13346-023-01357-0. Online ahead of print.ABSTRACTKaempferol (KAE) is a naturally occurring flavonoid compound with antitumor activity. However, the low aqueous solubility, poor chemical stability, and suboptimal bioavailability greatly restrict its clinical application in cancer therapy. To address the aforementioned limitations and augment the antitumor efficacy of KAE, we developed a kaempferol nanosuspensions (KAE-NSps) utilizing D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) as a stabilizing agent, screened the optimal preparation process, and conducted a comp...
Source: Cell Research - May 6, 2023 Category: Cytology Authors: Wen He Junfeng Zhang Jiale Ju Yinghua Wu Yuxi Zhang Lin Zhan Chenchen Li Yanli Wang Source Type: research
Exploring Purification Methods of Exosomes from Different Biological Samples
CONCLUSION: In this study, the extraction and separation methods of foreign bodies from different biological samples were obtained, and it was found that human breast milk was a potential excellent material for administration because of its high abundance.PMID:37124929 | PMC:PMC10132896 | DOI:10.1155/2023/2336536
Source: Cell Research - May 1, 2023 Category: Cytology Authors: Xiaoqing Qian Feng Xie Daxiang Cui Source Type: research
Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs
Antiviral Res. 2023 Mar 1:105575. doi: 10.1016/j.antiviral.2023.105575. Online ahead of print.ABSTRACTWith the resurgence of the coronavirus pandemic, the repositioning of FDA-approved drugs against coronovirus and finding alternative strategies for antiviral therapy are both important. We previously identified the viral lipid envelope as a potential target for the prevention and treatment of SARS-CoV-2 infection with plant alkaloids (Shekunov et al., 2021). Here, we investigated the effects of eleven cyclic lipopeptides (CLPs), including well-known antifungal and antibacterial compounds, on the liposome fusion triggered b...
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Egor V Shekunov Polina D Zlodeeva Svetlana S Efimova Anna A Muryleva Vladimir V Zarubaev Alexander V Slita Olga S Ostroumova Source Type: research
Elastin-like protein hydrogels with controllable stress relaxation rate and stiffness modulate endothelial cell function
J Biomed Mater Res A. 2023 Mar 2. doi: 10.1002/jbm.a.37520. Online ahead of print.ABSTRACTMechanical cues from the extracellular matrix (ECM) regulate vascular endothelial cell (EC) morphology and function. Since naturally derived ECMs are viscoelastic, cells respond to viscoelastic matrices that exhibit stress relaxation, in which a cell-applied force results in matrix remodeling. To decouple the effects of stress relaxation rate from substrate stiffness on EC behavior, we engineered elastin-like protein (ELP) hydrogels in which dynamic covalent chemistry (DCC) was used to crosslink hydrazine-modified ELP (ELP-HYD) and al...
Source: Cell Research - March 2, 2023 Category: Cytology Authors: Mahdis Shayan Michelle S Huang Renato Navarro Gladys Chiang Caroline Hu Beu P Oropeza Patrik K Johansson Riley A Suhar Abbygail A Foster Bauer L LeSavage Maedeh Zamani Annika Enejder Julien G Roth Sarah C Heilshorn Ngan F Huang Source Type: research
Targeted PEGylated Chitosan Nano-complex for Delivery of Sodium Butyrate to Prostate Cancer: An In Vitro Study
Conclusion: Hence, the synthesized Sb-loaded nano-complex could specifically suppress prostate cancer cell growth and induce apoptosis and autophagy in the molecular and cellular phases.PMID:36855824 | DOI:10.1177/15330338231159223
Source: Cell Research - March 1, 2023 Category: Cytology Authors: Ali Zamanvaziri Mahboobeh Meshkat Soroush Alazmani Sepideh Khaleghi Mehrdad Hashemi Source Type: research
Bioactive engineered scaffolds based on PCL-PEG-PCL and tumor cell-derived exosomes to minimize the foreign body reaction
Biomater Biosyst. 2022 Jun 14;7:100055. doi: 10.1016/j.bbiosy.2022.100055. eCollection 2022 Aug.ABSTRACTLong-term presence of M1 macrophages causes serious foreign body reaction (FBR), which is the main reason for the failure of biological scaffold integration. Inducing M2 polarization of macrophages near scaffolds to reduce foreign body response has been widely researched. In this work, inspired by the special capability of tumor exosomes in macrophages M2 polarization, we integrate tumor-derived exosomes into biological scaffolds to minimize the FBR. In brief, breast cancer cell-derived exosomes are loaded into polycapro...
Source: Cell Research - February 24, 2023 Category: Cytology Authors: Zehong Xiang Xinghua Guan Zhifang Ma Qiang Shi Mikhail Panteleev Fazly I Ataullakhanov Source Type: research
The influences of PEG-functionalized graphdiyne on cell growth and osteogenic differentiation of bone marrow mesenchymal stem cells
In this study, GDY was modified with polyethylene glycol (PEG) and the influences of GDY-PEG at different concentrations on BMSCs cell growth and osteogenic differentiation were researched for the first time. In this study, we found that GDY-PEG at low concentration possessed premium bio-compatibility and revealed evident facilitation of BMSCs osteogenic differentiation. The cell growth and osteogenic differentiation of BMSCs treated with GDY-PEG were dose-dependent. GDY-PEG at 1 μg/mL demonstrated the optimal promoting effects of BMSCs osteogenic differentiation. Moreover, the regulating effect of BMSCs osteogenic differ...
Source: Cell Research - February 10, 2023 Category: Cytology Authors: Yiming Li Ziqing Huang Xiaoqiong Huang Ruogu Xu Yi He Feilong Deng Guanhui Chen Source Type: research
