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Reduced Anticoagulant Effect of Dabigatran in a Patient Receiving Concomitant Phenytoin
We describe the first case report, to our knowledge, documenting a drug interaction between phenytoin and dabigatran by using laboratory measurements of dabigatran serum concentrations. A 45‐year‐old African‐American man was admitted to the inpatient cardiology service following defibrillations from his implantable cardioverter defibrillator. The patient was evaluated and received appropriate antitachycardia pacing for atrial tachyarrhythmias for an episode of ventricular tachycardia (VT), and antiarrhythmic therapy with sotalol was initiated to reduce both his AF and VT burden. On review of the patient's medications...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 5, 2016 Category: Drugs & Pharmacology Authors: Barbara S. Wiggins, Amanda Northup, Dominic Johnson, Jeffrey Senfield Tags: Case Report Source Type: research