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A dual kisspeptin-GnRH immunogen for reproductive immunosterilization
Vaccine. 2021 Sep 3:S0264-410X(21)00985-3. doi: 10.1016/j.vaccine.2021.07.080. Online ahead of print.ABSTRACTGnRH immunogens have been extensively employed in immunocontraception of animals. While they are effective, they are not 100% efficacious and of limited duration. GnRH secretion is dependent on upstream stimulation by kisspeptin. We therefore hypothesised that a dual immunogen combining GnRH and kisspeptin may be more efficacious through targeting two levels of the axis. We have previously shown GnRH immunogen elicits permanent sterilisation when sheep are vaccinated neonatally suggesting that the efficacy of GnRH i...
Source: Vaccine - September 7, 2021 Category: Allergy & Immunology Authors: Jesus A Junco Franklin Fuentes Robert P Millar Source Type: research
