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Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes
In this study, we identified CYP1A1, CYP1A2, CYP1B1, and CYP1D1 cDNAs from tree shrew liver and compared their characteristics with dog, pig, and human CYP1As. The deduced amino acid sequences of tree shrew CYP1s were highly identical (82-87 %) to human CYP1s. In tree shrews, CYP1A1 and CYP1A2 mRNAs were preferentially expressed in liver, whereas CYP1D1 mRNA was preferentially expressed in kidney and lung. In contrast, CYP1B1 mRNA was expressed in various tissues, with the most abundant expression in spleen. Among the tree shrew CYP1 mRNAs, CYP1A2 mRNA was most abundant in liver, and CYP1B1 mRNA was most abundant in kidney...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 23, 2022 Category: Biochemistry Authors: Yasuhiro Uno Yutaro Noda Norie Murayama Kyoko Tsukiyama-Kohara Hiroshi Yamazaki Source Type: research

A dual kisspeptin-GnRH immunogen for reproductive immunosterilization
Vaccine. 2021 Sep 3:S0264-410X(21)00985-3. doi: 10.1016/j.vaccine.2021.07.080. Online ahead of print.ABSTRACTGnRH immunogens have been extensively employed in immunocontraception of animals. While they are effective, they are not 100% efficacious and of limited duration. GnRH secretion is dependent on upstream stimulation by kisspeptin. We therefore hypothesised that a dual immunogen combining GnRH and kisspeptin may be more efficacious through targeting two levels of the axis. We have previously shown GnRH immunogen elicits permanent sterilisation when sheep are vaccinated neonatally suggesting that the efficacy of GnRH i...
Source: Vaccine - September 7, 2021 Category: Allergy & Immunology Authors: Jesus A Junco Franklin Fuentes Robert P Millar Source Type: research