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Source: Ecotoxicology and Environmental Safety
Drug: Estradiol
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Total 90 results found since Jan 2013.
Association between ambient air pollutants and birthweight of singletons following assisted reproductive technologies
CONCLUSIONS: Air pollution exposure during ART treatment may affect the birthweight of the offspring.PMID:37688862 | DOI:10.1016/j.ecoenv.2023.115454
Source: Ecotoxicology and Environmental Safety - September 9, 2023 Category: Environmental Health Authors: Xiaoming Jiang Jiali Cai Xinli Wang Lanlan Liu Jianzhi Ren Source Type: research
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice
In this study, 1 mg/kg of cadmium chloride (CdCl2) was injected intraperitoneally every other day in 8-week-old C57BL/6 J male mice to study the effects on their female offspring. Our results showed an increase in body weight, water intake and food intake in F1 female mice from the Cd-exposed group. The development of secondary follicles and antral follicles in the ovaries of Cd-treated was inhibited. Serum estradiol (E2) was found to be decreased. Further analysis revealed significant downregulation of StAR, P450scc, 17β-HSD, CYP17A1 and CYP19A1, which are related to E2 synthesis. Serum total cholesterol was increased an...
Source: Ecotoxicology and Environmental Safety - July 23, 2023 Category: Environmental Health Authors: Yanwei Zhang Jinzhao Zhou Ling Zeng Yifan Xiong Xiaofei Wang Wenpei Xiang Ping Su Source Type: research
Maternal genetic intergenerational and transgenerational effects on hormone synthesis in ovarian granulosa cells of offspring exposed to cadmium during pregnancy
This study aimed to investigate the maternally inherited intergenerational and transgenerational effects of cadmium (Cd) exposure on steroid hormone synthesis in the ovarian granulosa cells (GCs) of offspring rats. F1 rats were obtained by mating adult female Sprague-Dawley rats with healthy adult male rats and were exposed to 0, 0.5, 2.0, and 8.0 mg/kg CdCl2 during pregnancy. The adult female rats (PND 56) were mated with healthy adult male rats to produce F2 and F3 rats. The serum progesterone (Pg) and estradiol (E2) levels of the F2 adult female rats were decreased, while those of F3 rats were significantly increased. M...
Source: Ecotoxicology and Environmental Safety - July 23, 2023 Category: Environmental Health Authors: Lingfeng Luo Jingwen Li Yi Sun Yake Lv Jin Liu Yuchen Li Chenyun Zhang Wenchang Zhang Source Type: research
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice
In this study, 1 mg/kg of cadmium chloride (CdCl2) was injected intraperitoneally every other day in 8-week-old C57BL/6 J male mice to study the effects on their female offspring. Our results showed an increase in body weight, water intake and food intake in F1 female mice from the Cd-exposed group. The development of secondary follicles and antral follicles in the ovaries of Cd-treated was inhibited. Serum estradiol (E2) was found to be decreased. Further analysis revealed significant downregulation of StAR, P450scc, 17β-HSD, CYP17A1 and CYP19A1, which are related to E2 synthesis. Serum total cholesterol was increased an...
Source: Ecotoxicology and Environmental Safety - July 23, 2023 Category: Environmental Health Authors: Yanwei Zhang Jinzhao Zhou Ling Zeng Yifan Xiong Xiaofei Wang Wenpei Xiang Ping Su Source Type: research
Maternal genetic intergenerational and transgenerational effects on hormone synthesis in ovarian granulosa cells of offspring exposed to cadmium during pregnancy
This study aimed to investigate the maternally inherited intergenerational and transgenerational effects of cadmium (Cd) exposure on steroid hormone synthesis in the ovarian granulosa cells (GCs) of offspring rats. F1 rats were obtained by mating adult female Sprague-Dawley rats with healthy adult male rats and were exposed to 0, 0.5, 2.0, and 8.0 mg/kg CdCl2 during pregnancy. The adult female rats (PND 56) were mated with healthy adult male rats to produce F2 and F3 rats. The serum progesterone (Pg) and estradiol (E2) levels of the F2 adult female rats were decreased, while those of F3 rats were significantly increased. M...
Source: Ecotoxicology and Environmental Safety - July 23, 2023 Category: Environmental Health Authors: Lingfeng Luo Jingwen Li Yi Sun Yake Lv Jin Liu Yuchen Li Chenyun Zhang Wenchang Zhang Source Type: research
Effects of copper oxide nanoparticles on reproductive system of zebrafish
Ecotoxicol Environ Saf. 2023 Jul 17;263:115252. doi: 10.1016/j.ecoenv.2023.115252. Online ahead of print.ABSTRACTCopper oxide nanoparticles (CuO NPs) were regarded as the versatile materials in daily life and the in-depth evaluation of their biological effects is of great concern. Herein the female and male zebrafishes were chosen as the model animals to analyze the reproductive toxicity caused by CuO NPs at low concentration (10, 50 and 100 μg/L) After 20-days exposure, the structure of zebrafish ovary and testis were impaired. Moreover, the contents of 17β-estradiol (E2) in both females and males were increased, while ...
Source: Ecotoxicology and Environmental Safety - July 19, 2023 Category: Environmental Health Authors: Guizhu Wu Lu Gao Shaoming Zhang Daolin Du Yonglai Xue Source Type: research
Persistent high exposure to exogenous phthalates and endogenous sex hormones associated with early pubertal onset among children: A 3.5-year longitudinal cohort study in China
CONCLUSION: Long-term exposure to PAEs might increase the risk of early pubertal onset, and it appears to work in synergy with E2, while in antagonism with TT in boys' early pubertal onset. Reducing PAEs exposure might promote pubertal health.PMID:37390727 | DOI:10.1016/j.ecoenv.2023.115199
Source: Ecotoxicology and Environmental Safety - June 30, 2023 Category: Environmental Health Authors: Jieyu Liu Di Gao Yanhui Li Xinli Song Manman Chen Qi Ma Xinxin Wang Mengjie Cui Tongjun Guo Li Chen Yi Zhang Wen Yuan Tao Ma Jianuo Jiang Yanhui Dong Zhiyong Zou Jun Ma Source Type: research
Estradiol protects female mice from hyperuricemia induced by PCB138 exposure
Ecotoxicol Environ Saf. 2023 Jun 2;261:115093. doi: 10.1016/j.ecoenv.2023.115093. Online ahead of print.ABSTRACTPolychlorinated biphenyls (PCBs) are a type of persistent organic pollutant (POP). Our previous study demonstrated that exposure to 0.5-50 μg/kg bw PCB138 during postnatal days (PND) 3-21 led to elevated serum uric acid (UA) levels and kidney injury in adult male mice. Given that the prevalence of hyperuricemia (HUA) is significantly lower in women than in men, it is worth investigating whether POP-induced HUA and its secondary kidney injury have sexual dimorphism. Herein, we exposed female mice to 0.5-50 μg/kg...
Source: Ecotoxicology and Environmental Safety - June 4, 2023 Category: Environmental Health Authors: Changqian Liu Jinpeng Ruan Fengkai Ruan Xiaoyan Ding Changshun Han Chaoqun Huang Hongbin Zhong Chengyong He Zhenghong Zuo Jiyi Huang Source Type: research
Derivatized versus non-derivatized LC-MS/MS techniques for the analysis of estrogens and estrogen-like endocrine disruptors in human plasma
Ecotoxicol Environ Saf. 2023 Jun 1;260:115083. doi: 10.1016/j.ecoenv.2023.115083. Online ahead of print.ABSTRACTBisphenols, parabens, alkylphenols and triclosan are anthropogenic substances with a phenolic group that have been introduced to the environment in recent decades. As they possess hormone-like effects, they have been termed endocrine disruptors (EDs), and can interfere with steroid pathways in organisms. To evaluate the potential impact of EDs on steroid biosynthesis and metabolism, sensitive and robust methods enabling the concurrent measurement of EDs and steroids in plasma are needed. Of crucial importance is ...
Source: Ecotoxicology and Environmental Safety - June 3, 2023 Category: Environmental Health Authors: J Vitku L Horackova L Kolatorova M Duskova T Skodova M Simkova Source Type: research
Transcriptional, hormonal and histological alterations in the ovaries of BALB/c mice exposed to TCDD in connection with multigenerational female infertility
Ecotoxicol Environ Saf. 2023 May 6;258:114990. doi: 10.1016/j.ecoenv.2023.114990. Online ahead of print.ABSTRACT2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic congener of dioxins, has a proven reproductive toxicity. Due to the lack of evidence on the multigenerational female reproductive toxicity of TCDD through the maternal exposure, the current study aims to evaluate, on the one hand, the acute reproductive toxicity of TCDD on adult female pre-gestational exposed to a critical single dose of TCDD (25 μg/kg) for a week (group referred to as AFnG; adult female/non-gestation). On the other hand, the transcripti...
Source: Ecotoxicology and Environmental Safety - May 8, 2023 Category: Environmental Health Authors: Nour Aldeli Chadi Soukkarie Abdulsamie Hanano Source Type: research
