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Bound to bleed: How altered albumin binding may dictate warfarin treatment outcome
Publication date: March 2019Source: IJC Heart & Vasculature, Volume 22Author(s): Anke C. Fender, Dobromir DobrevAbstractAlthough non-vitamin-K anticoagulants are now the preferred option for stroke prevention in atrial fibrillation (AF), warfarin is still used in a significant number of patients. Warfarin dosing requirements are susceptible to drug interactions and genetic polymorphisms in metabolising enzymes. Human serum albumin (HSA) is a candidate modifier of warfarin pharmacokinetics, with hypoalbuminemia now shown to correlate with supratherapeutic INR levels and annual bleeding risk. Warfarin is highly bound to HSA,...
Source: IJC Heart and Vasculature - March 27, 2019 Category: Cardiology Source Type: research