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Left atrial appendage occlusion for prevention of stroke in nonvalvular atrial fibrillation: a meta-analysis
Conclusion Our data suggest that LAAO is a reasonable option for stroke prophylaxis in AF when anticoagulation is not an option, and the risk for stroke outweighs the risk of procedural complications. Data were limited with the use of most available devices. To better establish the risk and benefit of LAAO in comparison with standard therapy, more randomized controlled trials are necessary.
Source: Journal of Interventional Cardiac Electrophysiology - February 25, 2015 Category: Cardiology Source Type: research

The gap between indicated and prescribed stroke prevention therapies in a high-risk geriatric population
ConclusionsThis data set suggests that 37% of eligible elderly LTC residents failed to receive recommended stroke prevention therapies.
Source: Journal of Interventional Cardiac Electrophysiology - January 15, 2017 Category: Cardiology Source Type: research

Watchman outcomes comparing post-implantation anticoagulation with warfarin versus direct oral anticoagulants
ConclusionOur findings suggest that additional imaging or aggressive management of PDLs in Watchman recipients within the initial 6-month follow-up may aid in reducing stroke rates. Additionally, anticoagulation with DOACs ’ post Watchman implantation was found non-inferior to warfarin, with some evidence of lower risk for adverse outcomes favoring DOACs.
Source: Journal of Interventional Cardiac Electrophysiology - June 4, 2020 Category: Cardiology Source Type: research

Lower-adherence direct oral anticoagulant use is associated with increased risk of thromboembolic events than warfarin
ConclusionsIn this large real-world study, low adherence DOAC was associated with higher risk of TE events as compared to high and low adherence warfarin.
Source: Journal of Interventional Cardiac Electrophysiology - August 9, 2023 Category: Cardiology Source Type: research

Oral anticoagulant underutilization among elderly patients with atrial fibrillation: insights from the United States Medicare database
ConclusionsAlthough OAC therapy prescription is the standard of care for stroke prevention in AF patients, its overall utilization is still low among Medicare patients  ≥ 65 years old, with specific patient characteristics that predict underutilization.
Source: Journal of Interventional Cardiac Electrophysiology - July 9, 2022 Category: Cardiology Source Type: research

Clinical outcomes in patients with atrial fibrillation receiving amiodarone on NOACs vs. warfarin
ConclusionAmong patients with AF taking amiodarone, there is no increased risk of stroke, major bleeding, or ICB with NOACs compared to warfarin.
Source: Journal of Interventional Cardiac Electrophysiology - August 20, 2018 Category: Cardiology Source Type: research

Peri-procedural use of direct anticoagulation agents during cardiac device implantation: vitamin K antagonists vs direct oral anticoagulants
ConclusionUse of DOAC agents with transient interruption of one dose is as safe as warfarin in the peri-procedural setting during implantation of cardiac devices.
Source: Journal of Interventional Cardiac Electrophysiology - November 14, 2019 Category: Cardiology Source Type: research

Safety and effectiveness of compassionate use of LARIAT® device for epicardial ligation of anatomically complex left atrial appendages
Conclusions Despite a high preclusion rate, percutaneous LAA ligation may be safely and effectively performed on compassionate grounds using the first-generation LARIAT® device with surgical standby in patients with large and complex LAA.
Source: Journal of Interventional Cardiac Electrophysiology - January 17, 2015 Category: Cardiology Source Type: research

A randomized comparison of two direct oral anticoagulants for patients undergoing cardiac ablation with a contemporary warfarin control arm
ConclusionsThe incidence of asymptomatic cerebral micro-thromboembolism and hemopericardium in AF ablation was similar among patients using edoxaban, rivaroxaban, and warfarin. However, low doses of DOACs may increase the risk of asymptomatic stroke.
Source: Journal of Interventional Cardiac Electrophysiology - April 20, 2020 Category: Cardiology Source Type: research

Meta-analysis of efficacy and safety of new oral anticoagulants compared with warfarin in Japanese patients undergoing catheter ablation for atrial fibrillation
ConclusionsIn Japanese NVAF patients undergoing CA, NOACs have similar effects to warfarin in the prevention of stroke and systemic embolism. Moreover, NOACs were associated with a lower incidence of bleeding complications.
Source: Journal of Interventional Cardiac Electrophysiology - May 26, 2020 Category: Cardiology Source Type: research

Periprocedural and long-term safety and feasibility of direct oral anticoagulants in patients with biological valve undergoing radiofrequency catheter ablation for atrial fibrillation: a prospective multicenter study
ConclusionPeriprocedural and long-term administration of DOACs in patients with biological cardiac valves undergoing AF ablation appears as safe as warfarin therapy.
Source: Journal of Interventional Cardiac Electrophysiology - September 6, 2020 Category: Cardiology Source Type: research

High rates of oral anticoagulation in atrial fibrillation patients observed in a large multi-specialty health system in the Northeast
ConclusionsWe show dramatically increased OAC usage among patients with AF and that NOACs comprise the large majority of OACs compared with previous studies. This suggests an association between widespread adoption of NOACs and increased oral anticoagulation rates. Future directions include assessing barriers to oral anticoagulation and developing interventions to reduce disparity in OAC use between clinics.
Source: Journal of Interventional Cardiac Electrophysiology - October 20, 2022 Category: Cardiology Source Type: research