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Source: Journal of Stroke and Cerebrovascular Diseases
Drug: Clopidogrel
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Total 43 results found since Jan 2013.
Do the Antithrombotic Therapy at the Time of Intracerebral Hemorrhage Influence Clinical Outcome? Analysis between the Difference of Antiplatelet and Anticoagulant Agents and Clinical Course
Background: It is controversial whether taking antiplatelet agents (APs) or anticoagulant agents (ACs) could influence clinical outcome after intracerebral hemorrhage (ICH).Methods: We retrospectively investigated 557 ICH patients between September 2008 and August 2013. We reviewed patients' characteristics, hematoma volume, deterioration (hematoma expansion, surgical hematoma evacuation, or death), and clinical outcome in modified Rankin Scale.Results: A total of 397 were classified as neither AP nor AC (“Nothing”), 81 as single AP (44 as aspirin [ASA], 22 as clopidogrel or ticlopidine [CLP/TIC], 7 as cilostazol, 8 as...
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2014 Category: Neurology Authors: Takeshi Okada, Taizen Nakase, Masahiro Sasaki, Tatsuya Ishikawa Tags: Original Articles Source Type: research
Safety Evaluation of Substituting Clopidogrel for Ticlopidine in Japanese Patients with Ischemic Stroke—Hiroshima Ticlopidine, Clopidogrel Safe Exchange Trial
Source: Journal of Stroke and Cerebrovascular Diseases - February 19, 2014 Category: Neurology Authors: Tatsuo Kohriyama, Chie Mihara, Takakazu Yokoyama, Tsuyoshi Torii, Atsuo Yamada, Kazuhiro Takamatsu, Taisei Ota, Kouichi Noda, Satoshi Kataoka, Hijiri Ito, Eiichi Nomura, Toshiho Ohtsuki, Shiro Aoki, Tomohisa Nezu, Ikuko Takeda, Tomoya Mukai, Naohisa Hosom Tags: Original Articles Source Type: research
Is Acute Carotid Artery Stent Thrombosis an Avoidable Complication?
The most serious complication of carotid artery stenting (CAS) is acute carotid artery stent thrombosis (ACAST). ACAST is a very rare complication, but it may lead to dramatic and catastrophic consequences. The most important cause is inadequate or ineffective antiaggregant therapy. It is very important to identify, before CAS, those patients who might be candidates for ACAST and to start antiplatelet therapy for them. Testing patients who are candidates for CAS for acetylsalicylic acid and clopidogrel resistance may prevent this complication.
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2015 Category: Neurology Authors: Erkan Köklü, İsa Öner Yüksel, Nermin Bayar, Şakir Arslan Source Type: research
Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures
Optimal antiplatelet inhibition is essential in patients undergoing neurointerventional procedures; however, variability in response to clopidogrel can contribute to thromboembolic and hemorrhagic complications. The present study evaluated the influence of diabetes mellitus and cigarette smoking on clopidogrel reactivity.
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2015 Category: Neurology Authors: Ichiro Nakagawa, Hun Soo Park, Shohei Yokoyama, Takeshi Wada, Yasuo Hironaka, Yasushi Motoyama, Katsutoshi Takayama, Kimihiko Kichikawa, Hiroyuki Nakase Source Type: research
Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model
To understand whether the use of antiplatelet agents leads to less intra-aneurismal tissue formation following coil implantation in a rat end-pouch external carotid artery (ECA) aneurysm model.
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2016 Category: Neurology Authors: Chao Zhang, Peiliang Li, Guohua Xi, Joseph J. Gemmete, Neeraj Chaudhary, B. Gregory Thompson, Aditya S. Pandey Source Type: research
Effects With and Without Clopidogrel Loading Treatment for Acute Ischemic Cerebrovascular Disease Patients: A Retrospective Cohort Study
We investigated the effectiveness of clopidogrel loading (CL) treatment compared with usual clopidogrel non-loading (NL) treatment for acute ischemic cerebrovascular disease.
Source: Journal of Stroke and Cerebrovascular Diseases - August 18, 2017 Category: Neurology Authors: Yasuko Ikeda-Sakai, Masahiro Sasaki, Taizen Nakase Source Type: research
Evaluating the Effect of Six Proton Pump Inhibitors on the Antiplatelet Effects of Clopidogrel
The objective of the present study was to examine the robustness of this interaction using a well-controlled study design in a population of participants free of confounders.
Source: Journal of Stroke and Cerebrovascular Diseases - February 12, 2018 Category: Neurology Authors: Eugene R. Przespolewski, Erica S. Westphal, Michelle Rainka, Nicholas M. Smith, Vernice Bates, Fran M. Gengo Source Type: research
Comparison of Effects between Clopidogrel and Cilostazol on Cerebral Perfusion in Nonsurgical Adult Patients with Symptomatically Ischemic Moyamoya Disease: Subanalysis of a Prospective Cohort
Adult patients with symptomatically ischemic moyamoya disease (MMD) initially undergo medical treatment alone including antiplatelet drugs when symptomatic cerebral hemispheres do not exhibit hemodynamic compromise. The purpose of the present study subanalyzing the same patient cohort used in a previous study was to determine which antiplatelet drug, clopidogrel or cilostazol, provides better improvement of cerebral perfusion in such patients.
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2018 Category: Neurology Authors: Takayuki Chiba, Kengo Setta, Yasuyoshi Shimada, Jun Yoshida, Kentaro Fujimoto, Shouta Tsutsui, Kenji Yoshida, Masakazu Kobayashi, Yoshitaka Kubo, Shunrou Fujiwara, Kazunori Terasaki, Kuniaki Ogasawara Source Type: research
Predictors of Clopidogrel Hyper-Responsiveness in Neuro-Interventional Procedures
Hyper-responsiveness to clopidogrel abnormally inhibits platelet aggregation and increases hemorrhagic complications. The present study investigated clinical factors related to clopidogrel hyper-responsiveness in neuro-interventional procedures.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2020 Category: Neurology Authors: Ryotaro Suzuki, Masaya Nagaishi, Issei Takano, Tomoji Takigawa, Akio Hyodo, Kensuke Suzuki Source Type: research
P2Y12 reaction units and ischemic and bleeding events after neuro-endovascular treatment
To investigate the associations of perioperative P2Y12 reaction units (PRU) measured using VerifyNow with ischemic and bleeding events, and to determine the PRU threshold in the setting of elective neuro-endovascular treatment (EVT) for intracranial/extracranial vascular disease in patients taking aspirin and clopidogrel.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2022 Category: Neurology Authors: Kyohei Fujita, Shoko Fujii, Sakyo Hirai, Hiroto Yamaoka, Mariko Ishikawa, Jun Karakama, Kazunori Miki, Masataka Yoshimura, Shigeru Nemoto, Kazutaka Sumita Source Type: research
An elderly case with late carotid stent thrombosis: possible role of antiphospholipid antibodies
The case study speculates that the antiphospholipid antibodies acquired during the follow-up period of carotid artery stenting may cause late stent thrombosis that is resistant to direct oral anticoagulants. A 73-year-old man was hospitalized with complaints of weakness in the right lower extremity. The patient had undergone carotid artery stenting for symptomatic stenosis of the left internal carotid artery 6 years prior and had received antiplatelet therapy with clopidogrel 75 mg/day. As the patient had developed atrial fibrillation without stent stenosis at the age of 70 years, anticoagulation therapy with rivaroxaban...
Source: Journal of Stroke and Cerebrovascular Diseases - May 26, 2023 Category: Neurology Authors: Shinji Kitsuki, Kenji Fukuda, Tomonaga Matsushita, Yoshihisa Fukushima, Tetsuro Ago, Takanari Kitazono Tags: Case Report Source Type: research
