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Clopidogrel Plus Aspirin Versus Warfarin in Patients With Stroke and Aortic Arch Plaques Major Clinical Trial
Conclusions— Because of lack of power, this trial was inconclusive and results should be taken as hypothesis generating. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00235248.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Amarenco, P., Davis, S., Jones, E. F., Cohen, A. A., Heiss, W.-D., Kaste, M., Laouenan, C., Young, D., Macleod, M., Donnan, G. A., The Aortic Arch Related Cerebral Hazard Trial Investigators, Bladin, Chambers, Frayne, Hankey, Levi, Read, Ravaud, Tatlisuma Tags: Anticoagulants, Antiplatelets Major Clinical Trial Source Type: research

C-Reactive Protein as a Prognostic Marker After Lacunar Stroke: Levels of Inflammatory Markers in the Treatment of Stroke Study Clinical Sciences
Conclusions— Among recent lacunar stroke patients, hsCRP levels predict the risk of recurrent strokes and other vascular events. hsCRP did not predict the response to dual antiplatelets. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00059306.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Elkind, M. S. V., Luna, J. M., McClure, L. A., Zhang, Y., Coffey, C. S., Roldan, A., Del Brutto, O. H., Pretell, E. J., Pettigrew, L. C., Meyer, B. C., Tapia, J., White, C., Benavente, O. R., on behalf of the LIMITS Investigators, The LIMITS Investigators Tags: Cerebrovascular disease/stroke, Cerebral Lacunes, Epidemiology Clinical Sciences Source Type: research

Antiplatelet Treatment for Prevention of Cerebrovascular Events in Patients With Vascular Diseases: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— DAPT with clopidogrel and aspirin compared with aspirin effectively reduces the risk of total and ischemic stroke in the overall cohort consisting of patients with cardiovascular disease without increase in intracranial hemorrhage, as well as decreases the risk of a recurrent total stroke in patients with a previous stroke/transient ischemic attack. Our meta-analysis suggests that DAPT including low-dose aspirin (75–100 mg) and clopidogrel (75 mg) should be further investigated as a strategy to reduce recurrent strokes. Clinical Trial Registration— URL: http://www.crd.york.ac.uk/prospero. Un...
Source: Stroke - January 27, 2014 Category: Neurology Authors: Gouya, G., Arrich, J., Wolzt, M., Huber, K., Verheugt, F. W. A., Gurbel, P. A., Pirker-Kees, A., Siller-Matula, J. M. Tags: Antiplatelets Clinical Sciences Source Type: research

Antiplatelet Loading Improves Behavioral Outcome in a Rabbit Model of Stroke Brief Reports
Conclusions— This study suggests that usual dual antiplatelet loading is clinically beneficial in a validated model of acute stroke. Study of usual dual antiplatelet loading in acute stroke is warranted to provide treatment to stroke victims ineligible for current therapies.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Meyer, D. M., Compton, P., Eastwood, J.-A., Gylys, K., Zivin, J. A. Tags: Animal models of human disease, Aggregation, Platelet function inhibitors, Emergency treatment of Stroke, Antiplatelets Brief Reports Source Type: research

Risk of Subarachnoid Hemorrhage and Early Case Fatality Associated With Outpatient Antithrombotic Drug Use Clinical Sciences
Conclusions— Outpatient antithrombotic drug use was associated with an increased risk of SAH, but no association was observed with early case fatality.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Garbe, E., Kreisel, S. H., Behr, S. Tags: Heparin, Coumarins, Platelet function inhibitors, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Clinical Sciences Source Type: research

Letter by Dong et al Regarding Article, "CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China" Letters to the Editor
Source: Stroke - August 26, 2013 Category: Neurology Authors: Dong, Y., Cheng, X., Dong, Q. Tags: Antiplatelets Letters to the Editor Source Type: research

Response to Letter Regarding Article, "CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China" Letters to the Editor
Source: Stroke - August 26, 2013 Category: Neurology Authors: Zhang, M., Xu, Y. Tags: Antiplatelets Letters to the Editor Source Type: research

Urgent Best Medical Therapy May Obviate the Need for Urgent Surgery in Patients With Symptomatic Carotid Stenosis Clinical Sciences
Conclusions— CEA can be performed in the subacute period without significantly increasing the operative risk. The urgent best medical treatment was associated with significant reduction in the risk of early NR in CEA patients. It seems that urgent aggressive best medical treatment may obviate the need for urgent CEA.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Shahidi, S., Owen-Falkenberg, A., Hjerpsted, U., Rai, A., Ellemann, K. Tags: Secondary prevention, Antiplatelets, Carotid endarterectomy, Transient Ischemic Attacks Clinical Sciences Source Type: research

CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China Brief Reports
Conclusions— CYP2C19 genotypes had significant impact on clopidogrel response and prognosis of patients with stroke. Clinical Trial Registration Information— URL: http://www.chictr.org/. Unique Identifier: ChiCTR-OCH-12002681.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Jia, D.-m., Chen, Z.-b., Zhang, M.-j., Yang, W.-j., Jin, J.-l., Xia, Y.-q., Zhang, C.-l., Shao, Y., Chen, C., Xu, Y. Tags: Acute Cerebral Infarction, Genetics of Stroke Brief Reports Source Type: research

Clopidogrel Added to Aspirin Adds No Benefit but Bleeding Risk in Patients With Recent Lacunar Stroke Emerging Therapy Critiques
Source: Stroke - February 25, 2013 Category: Neurology Authors: Diener, H.-C., Weber, R. Tags: Secondary prevention, Cerebral Lacunes Emerging Therapy Critiques Source Type: research

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