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Clopidogrel Plus Aspirin Versus Warfarin in Patients With Stroke and Aortic Arch Plaques Major Clinical Trial
Conclusions— Because of lack of power, this trial was inconclusive and results should be taken as hypothesis generating. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00235248.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Amarenco, P., Davis, S., Jones, E. F., Cohen, A. A., Heiss, W.-D., Kaste, M., Laouenan, C., Young, D., Macleod, M., Donnan, G. A., The Aortic Arch Related Cerebral Hazard Trial Investigators, Bladin, Chambers, Frayne, Hankey, Levi, Read, Ravaud, Tatlisuma Tags: Anticoagulants, Antiplatelets Major Clinical Trial Source Type: research

Letter by Moris and Avgerinos Regarding Article, “Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone” Letter to the Editor
Source: Stroke - November 27, 2016 Category: Neurology Authors: Demetrios Moris, Efthymios Avgerinos Tags: Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Antiplatelet Treatment for Prevention of Cerebrovascular Events in Patients With Vascular Diseases: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— DAPT with clopidogrel and aspirin compared with aspirin effectively reduces the risk of total and ischemic stroke in the overall cohort consisting of patients with cardiovascular disease without increase in intracranial hemorrhage, as well as decreases the risk of a recurrent total stroke in patients with a previous stroke/transient ischemic attack. Our meta-analysis suggests that DAPT including low-dose aspirin (75–100 mg) and clopidogrel (75 mg) should be further investigated as a strategy to reduce recurrent strokes. Clinical Trial Registration— URL: http://www.crd.york.ac.uk/prospero. Un...
Source: Stroke - January 27, 2014 Category: Neurology Authors: Gouya, G., Arrich, J., Wolzt, M., Huber, K., Verheugt, F. W. A., Gurbel, P. A., Pirker-Kees, A., Siller-Matula, J. M. Tags: Antiplatelets Clinical Sciences Source Type: research

Urgent Best Medical Therapy May Obviate the Need for Urgent Surgery in Patients With Symptomatic Carotid Stenosis Clinical Sciences
Conclusions— CEA can be performed in the subacute period without significantly increasing the operative risk. The urgent best medical treatment was associated with significant reduction in the risk of early NR in CEA patients. It seems that urgent aggressive best medical treatment may obviate the need for urgent CEA.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Shahidi, S., Owen-Falkenberg, A., Hjerpsted, U., Rai, A., Ellemann, K. Tags: Secondary prevention, Antiplatelets, Carotid endarterectomy, Transient Ischemic Attacks Clinical Sciences Source Type: research

Clopidogrel Added to Aspirin Adds No Benefit but Bleeding Risk in Patients With Recent Lacunar Stroke Emerging Therapy Critiques
Source: Stroke - February 25, 2013 Category: Neurology Authors: Diener, H.-C., Weber, R. Tags: Secondary prevention, Cerebral Lacunes Emerging Therapy Critiques Source Type: research

Letter by Dong et al Regarding Article, "CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China" Letters to the Editor
Source: Stroke - August 26, 2013 Category: Neurology Authors: Dong, Y., Cheng, X., Dong, Q. Tags: Antiplatelets Letters to the Editor Source Type: research

Response to Letter Regarding Article, "CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China" Letters to the Editor
Source: Stroke - August 26, 2013 Category: Neurology Authors: Zhang, M., Xu, Y. Tags: Antiplatelets Letters to the Editor Source Type: research

Risk Factors of Subacute Thrombosis After Intracranial Stenting for Symptomatic Intracranial Arterial Stenosis Brief Report
Conclusions—Tandem stenting and antiplatelet resistance might contribute to the development of SAT after intracranial stenting in patients with symptomatic intracranial arterial stenosis.
Source: Stroke - February 26, 2017 Category: Neurology Authors: Xuan Sun, Xu Tong, Wai Ting Lo, Dapeng Mo, Feng Gao, Ning Ma, Bo Wang, Zhongrong Miao Tags: Stent, Ischemic Stroke, Stenosis, Thrombosis Brief Reports Source Type: research

Use of Platelet Function Testing Before Pipeline Embolization Device Placement Clinical Sciences
Conclusions—Clopidogrel nonresponders experienced a significantly higher rate of thromboembolic complications when compared with clopidogrel responders. However, this risk seems to be mitigated in nonresponders who were switched to ticagrelor or received a clopidogrel boost within 24 hours pre-procedure.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Nimer Adeeb, Christoph J. Griessenauer, Paul M. Foreman, Justin M. Moore, Hussain Shallwani, Rouzbeh Motiei-Langroudi, Abdulrahman Alturki, Adnan H. Siddiqui, Elad I. Levy, Mark R. Harrigan, Christopher S. Ogilvy, Ajith J. Thomas Tags: Treatment, Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures Original Contributions Source Type: research

Risk of Subarachnoid Hemorrhage and Early Case Fatality Associated With Outpatient Antithrombotic Drug Use Clinical Sciences
Conclusions— Outpatient antithrombotic drug use was associated with an increased risk of SAH, but no association was observed with early case fatality.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Garbe, E., Kreisel, S. H., Behr, S. Tags: Heparin, Coumarins, Platelet function inhibitors, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Clinical Sciences Source Type: research

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