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Drug: Methotrexate
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Predictors of Chemotherapy Induced Adverse Events in Pediatric Osteosarcoma Patients
CONCLUSION: Major adverse events are becoming more common in pediatric osteosarcoma patients, and risk factors include larger chemotherapy doses, higher plasma methotrexate concentrations, and a slower pre-hydration rate. The outcomes of the study could aid in the better treatment of toxicity in children with osteosarcoma.PMID:35092376 | DOI:10.31557/APJCP.2022.23.1.93
Source: Asian Pacific Journal of Cancer Prevention - January 29, 2022 Category: Cancer & Oncology Authors: Phitjira Sanguanboonyaphong Patcharee Komvilaisak Kunanya Suwannaying Jukapun Yoodee Manit Saeteaw Suthan Chanthawong Suphat Subongkot Source Type: research
Effect of an Extract from the Egyptian Sea Cucumber, Bohadschia marmorata, on Methotrexate-Induced Hepatorenal Toxicity in Male Mice
CONCLUSIONS: Biochemical analysis and histopathological examination of liver tissue showed that administration of MTX increased serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lowered levels of serum albumin, total protein, Superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Administration of B. marmorata extract to MTX- injected mice significantly reversed the increase in serum levels of liver enzymes and induced a significant elevation in serum albumin and total protein levels. SOD, CAT, and GSH levels returned to nearly normal levels. Histopathological examination indi...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2022 Category: Cancer & Oncology Authors: Manar Kandeil Eman El-Sayed El-Nahass Mona Elwan Source Type: research
