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Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Abstract Epilepsy comes after stroke as the most common chronic neurological disorder worldwide. Inflammation enhances neuronal hyperexcitability that could provide a background setting for the development of epilepsy. The aim of this study was to assess the effect of valproate (VAL), diclofenac (DIC), meloxicam (MEL), VAL + MEL and VAL + DIC in pentylenetetrazol (PTZ) kindled mice. Seventy mice were randomly allocated into 7 equal groups; Control, PTZ, VAL, DIC, MEL, VAL + MEL and VAL + DIC groups. Kindling was induced by PTZ (40 mg/kg, i.p.) injection every other day for 17 days. The drugs were...
Source: Neurochemical Research - May 12, 2020 Category: Neuroscience Authors: Elgarhi R, Shehata MM, Abdelsameea AA, Salem AE Tags: Neurochem Res Source Type: research