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Potential of mRNA vaccines to become versatile cancer vaccines
World J Clin Oncol. 2022 Aug 24;13(8):663-674. doi: 10.5306/wjco.v13.i8.663.ABSTRACTFor centuries, therapeutic cancer vaccines have been developed and tried clinically. Way back in the late 19th century, the Father of Immunotherapy, William Coley had discovered that bacterial toxins were effective for inoperable sarcomas. In the 1970s, the Bacillus Calmette-Guérin (BCG) vaccine was repurposed, e.g., for advanced melanomas. Then, therapeutic cancer vaccines based on tumor-associated antigens (found on the surfaces of cancer cells) were tried clinically but apparently have not made a really significant clinical impact. For ...
Source: Clinical Prostate Cancer - September 26, 2022 Category: Cancer & Oncology Authors: Shiu-Ying Tsao Source Type: research