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Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade
This study aims to investigate the effect of curcumin (Cur) and resveratrol (Res) as a potential combination therapy on MAFLD. Cur, Res and Cur+Res were tested in palmitic acid (PA)-induced-HepG2 cells. MAFLD model was established using Goto-Kakizaki rats. The animals were treated with vehicle control (model group), Cur (150 mg/kg), Res (150 mg/kg), Cur+Res (150 mg/kg, 8:2, w/w), or metformin (Met, positive control, 400 mg/kg/day) via oral gavage for 4 weeks. Wistar rats were used as the control group. Network pharmacology was conducted to elucidate the molecular actions of Cur and Res, followed by q-PCR and immunoblotting...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2023 Category: Drugs & Pharmacology Authors: Yuhui He Huan Wang Shiling Lin Tao Chen Dennis Chang Yibin Sun Chenxiang Wang Yang Liu Yusheng Lu Jianyuan Song Shaohua Li Wen Xu Yanxiang Lin Yanfang Zheng Xian Zhou Qiumei Huang Mingqing Huang Source Type: research

Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins
Biomed Pharmacother. 2023 Aug 1;165:115263. doi: 10.1016/j.biopha.2023.115263. Online ahead of print.ABSTRACTIn addition to the anti-diabetic effect of metformin, a growing number of studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which have potent, that can treat other disorders other than diabetes mellitus. We aimed to describe and review the protective and antidotal efficacy of metformin against biologicals, chemicals, natural, medications, pesticides, and radiation-induced toxicities. A comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2023 Category: Drugs & Pharmacology Authors: Amirhossein Malaekeh-Nikouei Sina Shokri-Naei Sobhan Karbasforoushan Hossein Bahari Vafa Baradaran Rahimi Reza Heidari Vahid Reza Askari Source Type: research

The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats
In conclusion, Met combined with TFRD ameliorated bone mass in osteoporotic rats through regulating Wnt/β-catenin signaling pathway and OPG/RANKL/RANK axis.PMID:37473680 | DOI:10.1016/j.biopha.2023.115181
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 20, 2023 Category: Drugs & Pharmacology Authors: Ningning Jiang Hui Jin Kun Yang Zhongyuan Zhang Wenshu Xu Xiaoxue Chen Zhenhua Zhang Hui Xu Source Type: research

Metformin protects fibroblasts from patients with GNE myopathy by restoring autophagic flux via an AMPK/mTOR-independent pathway
Biomed Pharmacother. 2023 May 29;164:114958. doi: 10.1016/j.biopha.2023.114958. Online ahead of print.ABSTRACTUDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) myopathy is an autosomal recessive disease characterized by rimmed vacuoles (RVs). Previous studies have shown that metformin protects against several neuromuscular disorders. In the present study, we summarize the clinical features of three GNE patients with the p.D207V mutation. The pathogenesis of GNE myopathy is described, and the significance of metformin in this disease is observed. Skin biopsy-derived fibroblasts from patients with GNE myop...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 1, 2023 Category: Drugs & Pharmacology Authors: Tongtong Zhang Xiang Yin Xuefan Yu Ren Shang Liuzhe Lu Jing Miao Source Type: research

Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy
Biomed Pharmacother. 2023 May 22;164:114911. doi: 10.1016/j.biopha.2023.114911. Online ahead of print.ABSTRACTBreast cancers (BCs) remain the leading cause of cancer-related deaths among women worldwide. Among the different types of BCs, treating the highly aggressive, invasive, and metastatic triple-negative BCs (TNBCs) that do not respond to hormonal/human epidermal growth factor receptor 2 (HER2) targeted interventions since they lack ER/PR/HER2 receptors remains challenging. While almost all BCs depend on glucose metabolism for their proliferation and survival, studies indicate that TNBCs are highly dependent on glucos...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2023 Category: Drugs & Pharmacology Authors: Samson Mathews Samuel Elizabeth Varghese Noothan Jyothi Satheesh Chris R Triggle Dietrich B üsselberg Source Type: research

The F/B ratio as a biomarker for inflammation in COVID-19 and T2D: Impact of metformin
In this study, 115 participants were recruited and divided into three groups: 1st group: T2D patients and healthy controls, 2nd group: COVID-19 patients with and without T2D, 3rd group: T2D patients with COVID-19 treated with or without metformin. Gut microbial composition at the phylum level was assessed using qRT-PCR with universal primers targeting the bacterial 16 S rRNA gene and specific primers for Firmicutes and Bacteroidetes. Data was analyzed using one-way ANOVA, logistic regression, and Spearman's rank correlation coefficient. The study found that the ratio of Firmicutes to Bacteroidetes (F/B) was higher in patie...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 17, 2023 Category: Drugs & Pharmacology Authors: Pavlo Petakh Valentyn Oksenych Aleksandr Kamyshnyi Source Type: research

The ameliorative effect of zinc acetate with caffeic acid in the animal model of type 2 diabetes
Biomed Pharmacother. 2023 Apr 27;163:114779. doi: 10.1016/j.biopha.2023.114779. Online ahead of print.ABSTRACTRecently the complexation-mediated antioxidative and glycaemic control synergism between zinc(II) and caffeic acid was demonstrated in vitro. The present study evaluated the complexation-mediated antidiabetic and antioxidative synergism between zinc(II) and caffeic acid in diabetic rats and the possible underlying mechanisms. Male SD rats were induced with diabetes using 10% fructose and 40 mg/kg bw streptozotocin. The diabetic rats were treated with Zn(II)-caffeic acid complex and its precursors (caffeic acid and ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 29, 2023 Category: Drugs & Pharmacology Authors: Godfrey R Matowane Samson S Mashele Tshepiso J Makhafola Chika I Chukwuma Source Type: research

Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases
This study shows that BBR may be a good alternative for MTF in treating diabetic patients, especially for those complicated with dyslipidemia and obesity.PMID:37094549 | DOI:10.1016/j.biopha.2023.114754
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2023 Category: Drugs & Pharmacology Authors: Hui-Hui Guo Hao-Ran Shen Lu-Lu Wang Zhi-Gang Luo Jin-Lan Zhang Hong-Juan Zhang Tian-Le Gao Yan-Xing Han Jian-Dong Jiang Source Type: research

Doxorubicin downregulates autophagy to promote apoptosis-induced dilated cardiomyopathy via regulating the AMPK/mTOR pathway
In this study, Met significantly attenuated the oxidative stress response of myocardial tissue caused by DOX and activated cardiomyocyte autophagy to maintain cardiomyocyte energy metabolism and reduce cardiomyocyte apoptosis by downregulating mTOR activity. Overall, our study revealed the role of autophagy and apoptosis in DOX-induced dilated cardiomyopathy and demonstrated the potential role of regulation of the AMPK/mTOR axis in the treatment of DOX-induced dilated cardiomyopathy.PMID:37060659 | DOI:10.1016/j.biopha.2023.114691
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 15, 2023 Category: Drugs & Pharmacology Authors: Sheng Zhang Xueping Wei Haijin Zhang Youping Wu Junsong Jing Rongrong Huang Ting Zhou Jingjin Hu Yueguo Wu Yuanyuan Li Zhenqiang You Source Type: research

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