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Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo.
Abstract A significant increase in cardiovascular medication use during pregnancy occurred in recent years. Only limited evidence on safety profiles is available and little is known about the mechanisms of adverse effect on the fetus. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. Embryotoxicity was tested in ovo after administration of various doses of metoprolol, carvedilol, or ivabradine. Embryonic day (ED) 4 and 8 chick embryos were studied by video microscopy and ultrasound biomicroscopy ex ovo after intraamniotic injection of the drug for a period of 30 minu...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 11, 2013 Category: Physiology Authors: Kockova R, Svatunkova J, Novotny J, Hejnova L, Ostadal B, Sedmera D Tags: Am J Physiol Heart Circ Physiol Source Type: research

Carvedilol and Exercise Combination Therapy Improves Systolic but not Diastolic Function and Reduces Plasma Osteopontin in Col4a3-/- Mice
Am J Physiol Heart Circ Physiol. 2021 Mar 26. doi: 10.1152/ajpheart.00535.2020. Online ahead of print.ABSTRACTThere are currently no FDA-approved treatments for heart failure with preserved ejection fraction (HFpEF). Here we compared the effects of exercise with and without α/β-adrenergic blockade with carvedilol in Col4a3-/- Alport mice, a model of the Phenogroup 3 subclass of HFpEF with underlying renal dysfunction. Alport mice were assigned to the following groups: no treatment control (n=29), carvedilol (n=11), voluntary exercise (n=9), combination carvedilol and exercise (n=8). Cardiac function was assessed by echoc...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 26, 2021 Category: Physiology Authors: Julian C Dunkley Camila I Irion Keyvan Yousefi Serene A Shehadeh Guerline Lambert Krista John-Williams Keith A Webster Jeffrey J Goldberger Lina A Shehadeh Source Type: research