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Drug: Temodar
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Total 44 results found since Jan 2013.
ZNF300 enhances temozolomide resistance in gliomas by regulating lncRNA SNHG12
This study is designed to appraise the effects of ZNF300 on TMZ-resistance in gliomas. The TMZ-resistant glioma cell lines were established in U251 and A-172 cells. ZNF300 was significantly upregulated in TMZ-resistant glioma cells. ZNF300 depletion remodel TMZ sensitivity of glioma cells through inhibiting cell proliferation and promoting cell apoptosis. Meanwhile, ZNF300 depletion brought down-regulation of c-myc and SNHG12 which could be counteracted by overexpression of c-myc. Moreover, SNHG12 performed as the downstream of ZNF300 and c-myc, and overexpression of SNHG12 also could neutralize the effects of ZNF300 deple...
Source: General Physiology and Biophysics - August 8, 2022 Category: Physiology Authors: Junqi Fu Jun Peng Guolong Tu Source Type: research
