• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

On optimal temozolomide scheduling for slowly growing glioblastomas
CONCLUSIONS: In-silico simulations, in-vitro and in-vivo studies show that TMZ administration schedules with increased time between doses may reduce toxicity, delay the appearance of resistances and lead to survival benefits mediated by changes in the tumor phenotype in slowly-growing GBMs.PMID:36325374 | PMC:PMC9616068 | DOI:10.1093/noajnl/vdac155
Source: Adv Data - November 3, 2022 Category: Epidemiology Authors: Berta Segura-Collar Juan Jim énez-Sánchez Ricardo Gargini Miodrag Dragoj Juan M Sep úlveda-Sánchez Milica Pe šić Mar ía A Ramírez Luis E Ayala-Hern ández Pilar S ánchez-Gómez V íctor M Pérez-García Source Type: research

Abstract 5222: Endothelial plasticity generates aberrant angiogenesis and therapy resistance in glioblastoma
Overgrown, abnormal vasculature characterizes the microenvironment that fuels cancer progression and induces therapeutic resistance. Here we reveal that endothelial plasticity drives excessive and abnormal tumor angiogenesis. Glioblastoma multiforme (GBM) is among the most lethal of human malignancies, distinguished by prominent vascularity and extreme vascular abnormality. We identify endothelial fibro-transformation (Endo-FT) in GBM, contributing significantly to aberrant vascularization, tumor progression, and therapeutic resistance. Utilizing human GBM specimens and allograft and genetic murine GBM models driven by RCA...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Huang, M., Fan, Y. Tags: Tumor Biology Source Type: research