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Paclitaxel and naringenin-loaded solid lipid nanoparticles surface modified with cyclic peptides with improved tumor targeting ability in glioblastoma multiforme
Biomed Pharmacother. 2021 Mar 8;138:111461. doi: 10.1016/j.biopha.2021.111461. Online ahead of print.ABSTRACTThe present work describes the systematic development of paclitaxel and naringenin-loaded solid lipid nanoparticles (SLNs) for the treatment of glioblastoma multiforme (GBM). So far only temozolomide therapy is available for the GBM treatment, which fails by large amount due to poor brain permeability of the drug and recurrent metastasis of the tumor. Thus, we investigated the drug combination containing paclitaxel and naringenin for the treatment of GBM, as these drugs have individually demonstrated significant pot...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 11, 2021 Category: Drugs & Pharmacology Authors: Liying Wang Xiangbo Wang Lina Shen Majed Alrobaian Sunil K Panda Hussain A Almasmoum Mazen M Ghaith Riyad A Almaimani Ibrahim Abdel Aziz Ibrahim Tanuja Singh Abdullah A Baothman Hani Choudhry Sarwar Beg Source Type: research