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Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder
CONCLUSIONS: Our findings show that ketamine and esketamine may be more efficacious than placebo at 24 hours. How these findings translate into clinical practice, however, is not entirely clear. The evidence for use of the remaining glutamate receptor modulators is limited as very few trials were included in the meta-analyses for each comparison and the majority of comparisons included only one study. Long term non-inferiority RCTs comparing repeated ketamine and esketamine, and rigorous real-world monitoring are needed to establish comprehensive data on safety and efficacy.PMID:34510411 | DOI:10.1002/14651858.CD011612.pub3
Source: Cochrane Database of Systematic Reviews - September 12, 2021 Category: General Medicine Authors: Rebecca L Dean Claudia Hurducas Keith Hawton Styliani Spyridi Philip J Cowen Sarah Hollingsworth Tahnee Marquardt Annabelle Barnes Rebecca Smith Rupert McShane Erick H Turner Andrea Cipriani Source Type: research

Ketamine and other glutamate receptor modulators for depression in adults.
CONCLUSIONS: We found limited evidence for ketamine's efficacy over placebo at time points up to one week in terms of the primary outcome, response rate. The effects were less certain at two weeks post-treatment. No significant results were found for the remaining ten glutamate receptor modulators, except for sarcosine being more effective than citalopram at four weeks. In terms of adverse events, the only significant differences in favour of placebo over ketamine were in regards to confusion and emotional blunting. Despite the promising nature of these preliminary results, our confidence in the evidence was limited by ris...
Source: Cochrane Database of Systematic Reviews - September 23, 2015 Category: Journals (General) Authors: Caddy C, Amit BH, McCloud TL, Rendell JM, Furukawa TA, McShane R, Hawton K, Cipriani A Tags: Cochrane Database Syst Rev Source Type: research