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Drug: Acetylcysteine
Procedure: Perfusion
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Total 16 results found since Jan 2013.
N-acetylcysteine Treatment Attenuates Hemodialysis Access-related Limb Pathophysiology in Mice with Chronic Kidney Disease
The objective of this study was to determine if treatment with N-acetylcysteine (NAC) could reduce access-related limb dysfunction in mice. Male and female C57BL6J mice were fed an adenine supplemented diet to induce chronic kidney disease prior to surgical creation of an arteriovenous fistula (AVF) in the iliac vascular bundle. AVF creation significantly increased peak aortic and infrarenal vena cava blood flow velocities, but NAC treatment had no significant impact indicating that fistula maturation was not impacted by NAC treatment. Hindlimb muscle and paw perfusion recovery and muscle capillary density in the AVF limb ...
Source: American Journal of Physiology. Renal Physiology - July 13, 2023 Category: Physiology Authors: Kyoungrae Kim Tomas A Cort Eric M Kunz Jack Moerschel Victoria R Palzkill Gengfu Dong Chatick N Moparthy Erik M Anderson Brian Fazzone Kerri A O'Malley Scott T Robinson Scott A Berceli Terence E Ryan Salvatore T Scali Source Type: research
Elevated LDL (Low-Density Lipoprotein) Cholesterol Increases Microvascular Endothelial VWF (von Willebrand Factor) and Thromboinflammation After Myocardial Infarction
CONCLUSIONS: In reperfused myocardial infarction, elevated LDL cholesterol promotes thromboinflammation through excess microvascular endothelial VWF and platelet adhesion, resulting in less microvascular reflow and larger infarct size. In the presence of elevated LDL cholesterol, therapies that suppress endothelial-associated VWF can promote recovery of left ventricular function and protect against remodeling.PMID:37128919 | DOI:10.1161/ATVBAHA.122.318884
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2023 Category: Cardiology Authors: Koya Ozawa William Packwood Oleg Varlamov Matthew Muller Aris Xie Melinda D Wu Rue-Jen Abraham-Fan Jos é A López Jonathan R Lindner Source Type: research
