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Engineered lipid liquid crystalline nanoparticles as an inhaled nanoplatform for mucus penetration enhancement
In this study, a lipid liquid crystalline nanoparticle NLP@Z with surface zwitterion material hexadecyl betaine (HB) modification and N-acetylcysteine (NAC) encapsulation was presented to exert the combination strategy of mucus-inert surface and mucus degradation. The HB modification endowed NLP@Z mucus-inert surface to inhibit the interaction between NLP@Z and mucins, and the encapsulated NAC could effectively degrade the mucins and further decrease the mucus viscosity. This combination strategy was proved to significantly promote the mucus penetration performance and enhance epithelial cell uptake. In addition, the propo...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Wenhao Wang Jingxuan Zeng Peili Luo Jiayi Fang Qingao Pei Jinwu Yan Chune Zhu Wei Chen Yanyun Liu Zhengwei Huang Ying Huang Chuanbin Wu Xin Pan Source Type: research
