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Source: Chemico-Biological Interactions
Drug: Acetylcysteine
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Total 32 results found since Jan 2013.
Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner
In this study, we examined the effect of varying doses and exposure times of hesperetin on MCF-7 and MDA-MB-231 cancer cells, as well as MCF-10A normal cells. By using MTT assay, real-time PCR, western blot, and flow cytometry, we determined the effects of Hst on cell viability, ROS levels, and markers of cell death. Furthermore, molecular docking was used to identify Hst targets that might be involved in ROS-dependent cell death. According to the results, different concentrations of Hst induced different modes of cell death at specific ROS levels. Paraptosis occurred in all cell lines at concentration ranges of IC35 to IC...
Source: Chemico-Biological Interactions - July 24, 2023 Category: Molecular Biology Authors: Mohammad Rasoul Samandari-Bahraseman Babak Khorsand Sara Zareei Massoud Amanlou Hanieh Rostamabadi Source Type: research
ROS and DRP1 interactions accelerate the mitochondrial injury induced by polystyrene nanoplastics in human liver HepG2 cells
Chem Biol Interact. 2023 Apr 19:110502. doi: 10.1016/j.cbi.2023.110502. Online ahead of print.ABSTRACTMicroplastics have become a serious environmental pollutant and subsequently have harmful effects on human health. Thus, the impacts of microplastics on human cells need to be explored. In the present study, the cytotoxic effects at the subcellular-organelle levels to polystyrene nanoplastics (PS-NPs, diameter 21.5 ± 2.7 nm) were investigated in the human hepatocellular carcinoma (HepG2) cell line. The cell viability exposed to PS-NPs at the concentrations of 6.25, 12.5, 25 and 50 μg/mL for 24 h diminished in a concentra...
Source: Chemico-Biological Interactions - April 21, 2023 Category: Molecular Biology Authors: Yunjing Li Menghao Guo Shuyan Niu Mengting Shang Xiaoru Chang Zuoyi Sun Rui Zhang Xin Shen Yuying Xue Source Type: research
Capsaicin toxicity to the yeast Saccharomyces cerevisiae is not due to oxidative stress but to disruption of membrane structure
Chem Biol Interact. 2023 Feb 17:110407. doi: 10.1016/j.cbi.2023.110407. Online ahead of print.ABSTRACTCapsaicin (CAP) is a common food constituent, conferring a pungent taste to red peppers of the genus Capsicum. It has bactericidal and fungicidal activity. The study was aimed to test the hypothesis of whether oxidative stress mediates the toxicity of CAP to the baker's yeast Saccharomyces cerevisiae as a model yeast. CAP showed good antioxidant properties (1.30 and 1.10 mol Trolox equivalents/mol in the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate (ABTS) radical scavenging assay and the Ferric Reducing Antioxidant Po...
Source: Chemico-Biological Interactions - February 22, 2023 Category: Molecular Biology Authors: Klaudia Kuczera Katarzyna Napar ło Miros ław Soszyński Grzegorz Bartosz Izabela Sadowska-Bartosz Source Type: research
N-acetylcysteine delayed cadmium-induced chronic kidney injury by activating the sirtuin 1-P53 signaling pathway
Chem Biol Interact. 2022 Dec 6:110299. doi: 10.1016/j.cbi.2022.110299. Online ahead of print.NO ABSTRACTPMID:36493885 | DOI:10.1016/j.cbi.2022.110299
Source: Chemico-Biological Interactions - December 9, 2022 Category: Molecular Biology Authors: Wenxuan Dong Kanglei Zhang Zhonggui Gong Tongwang Luo Jiahui Li Xueru Wang Hui Zou Ruilong Song Jiaqiao Zhu Yonggang Ma Gang Liu Zongping Liu Source Type: research
Aluminum activates NLRP3 inflammasome-mediated pyroptosis via reactive oxygen species to induce liver injury in mice
Chem Biol Interact. 2022 Oct 27;368:110229. doi: 10.1016/j.cbi.2022.110229. Online ahead of print.ABSTRACTAluminum (Al) exposure can lead to oxidative stress and liver inflammatory injury in mice. The overproduction of reactive oxygen species (ROS) activates the NLRP3 inflammasome and further induces liver pyroptosis. However, the participation of pyroptosis in inducing Al-mediated liver injury and the underlying regulatory mechanisms remain largely unclear. Herein, a mice model of subchronic Al exposure was established to investigate the role of pyroptosis in Al-induced liver injury. Then, MCC950 and N-acetylcysteine were...
Source: Chemico-Biological Interactions - November 10, 2022 Category: Molecular Biology Authors: Bo Li Xuliang Zhang Siming Huo Jian Zhang Jiayu Du Bonan Xiao Miao Song Bing Shao Yanfei Li Source Type: research
Lowering of brain endothelial cell barrier function by exposure to 4'-iodo- α-pyrrolidinononanophenone
In this study, we found that exposure to 4'-iodo-α-pyrrolidinononanophenone (I-α-PNP), one of the most potently cytotoxic PPs, at sublethal concentrations decreases trans-endothelial electrical resistance and increases paracellular permeability across a monolayer of human brain microvascular endothelial cells. Treatment with I-α-PNP also elevated the production of superoxide anion. Furthermore, the treatment reduced the expression and plasma membrane localization of a tight junction protein claudin-5 (CLDN5), which was almost restored by pretreatment with an antioxidant N-acetyl-l-cysteine. These results indicate that I...
Source: Chemico-Biological Interactions - July 25, 2022 Category: Molecular Biology Authors: Yuji Sakai Maki Taguchi Yoshifumi Morikawa Koichi Suenami Emiko Yanase Tomohiro Takayama Akira Ikari Toshiyuki Matsunaga Source Type: research
