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Source: Cell Research
Drug: Acetylcysteine
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Total 46 results found since Jan 2013.
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd
This study aimed to examine the impact of AlCl3 exposure on mitophagy and mitochondrial apoptosis in testicular tissue and mouse spermatocytes. Reactive oxygen species (ROS) and ATP levels were measured in GC-2spd after AlCl3 exposure using a multifunctional enzyme labeler. The changes in mitochondrial membrane potential (MMP) and TUNEL were observed through confocal laser microscopy, and the expression of proteins associated with mitophagy and apoptosis was analyzed using Western blot. Our results demonstrated that AlCl3 exposure disrupted mitophagy and increased apoptosis-related protein expression in testicular tissues....
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Hui- Xin Peng Fu Chai Ke-Heng Chen Yan-Xin Huang Guang-Ji Wei Huixiong Yuan Yan-Fang Pang Shi-Hua Luo Chun-Fang Wang Wen-Cheng Chen Source Type: research
Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells
Int J Mol Sci. 2023 Aug 9;24(16):12590. doi: 10.3390/ijms241612590.ABSTRACTMultiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative a...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anna Staskiewicz Erica Wong Michael Tucker Riya Farhin Jonathan Park Rana Saade Tina Alkhazali Tu Dang Xinyu Wang Source Type: research
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study
CONCLUSION: The results of this study support the significant hepatoprotective effect of SLB nanoliposomes against acetaminophen-induced toxicity depending on the route of administration.PMID:37506470 | DOI:10.1016/j.bbrc.2023.07.045
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Fatemeh Gheybi Alireza Khooei Azam Hoseinian Maham Doagooyan Kebria Houshangi Mahmoud Reza Jaafari Arash Papi Zahra Khoddamipour Amirhossein Sahebkar Seyedeh Hoda Alavizadeh Source Type: research
Evidence for the Metabolic Activation of Deferasirox < em > In Vitro < /em > and < em > In Vivo < /em >
Chem Res Toxicol. 2023 Jul 12. doi: 10.1021/acs.chemrestox.2c00416. Online ahead of print.ABSTRACTDeferasirox (DFS) is used for the treatment of iron accumulation caused by the need for long-term blood transfusions, such as thalassemia or other rare anemia. Liver injury due to exposure to DFS has been documented, and the toxic mechanisms of DFS are unknown. The present study aimed to investigate the reactive metabolites of DFS in vitro and in vivo to help us understand the mechanisms of DFS hepatotoxicity. Two hydroxylated metabolites (5-OH and 5'-OH) were identified during incubation of DFS-supplemented rat liver microsom...
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Mengdie Su Yanjia Zhao Mei Li Chenyang Jia He Liu Yue Zhang Weiwei Li Ying Peng Jiang Zheng Source Type: research
Reactive oxygen species-mediated endoplasmic reticulum stress contributes to osteocyte death induced by orthodontic compressive force
This study first proposes the ERS pathway as a new potential pathway for regulating the rate of OTM based on osteocyte death. RESEARCH HIGHLIGHTS: The orthodontic force increases osteocyte death in rat alveolar bone. The compressive force causes osteocyte apoptosis by the endoplasmic reticulum stress (ERS) pathway in vitro. The ROS scavenger NAC blocked compressive force-induced ERS and osteocyte apoptosis.PMID:37382312 | DOI:10.1002/jemt.24382
Source: Cell Research - June 29, 2023 Category: Cytology Authors: Ming Yan Yun Zhang Wanting Niu Kezhou Liu Lingyun Xue Kexin Zhou Source Type: research
NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF- κB pathway in macrophages
In this study, the expression of NAT10 in macrophages was found to decrease during LPS-induced inflammation. NAT10 knockdown significantly reduced the generation of inflammatory factors, while NAT10 overexpression had the opposite effect. RNA sequencing revealed that the differentially expressed genes were enriched in the NF-κB signalling pathway and oxidative stress. Both the NF-κB inhibitor Bay11-7082 and the ROS scavenger N-acetyl-L-cysteine (NAC) could reverse the upregulation of inflammatory factors. NAC inhibited the phosphorylation of NF-κB, but Bay11-7082 had no effect on the production of ROS in NAT10-overexpre...
Source: Cell Research - June 12, 2023 Category: Cytology Authors: Zhanqi Zhang Yiwen Zhang Yongjie Cai Di Li Jinlin He Zhihui Feng Qiong Xu Source Type: research
Anti-Warburg effect via generation of ROS and inhibition of PKM2/ β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
Phytother Res. 2023 May 26. doi: 10.1002/ptr.7903. Online ahead of print.ABSTRACTTo elucidate the underlying antitumor mechanism of lambertianic acid (LA) derived from Pinus koraiensis, the role of cancer metabolism related molecules was investigated in the apoptotic effect of LA in DU145 and PC3 prostate cancer cells. MTT assay for cytotoxicity, RNA interference, cell cycle analysis for sub G1 population, nuclear and cytoplasmic extraction, lactate, Glucose and ATP assay by ELISA, Measurement of reactive oxygen species (ROS) generation, Western blotting, and immunoprecipitation assay were conducted in DU145 and PC3 prosta...
Source: Cell Research - May 26, 2023 Category: Cytology Authors: Ji-Na Pak Hyo-Jung Lee Deok Yong Sim Ji Eon Park Chi-Hoon Ahn Su-Yeon Park Jae-Ho Khil Bumsang Shim Bonglee Kim Sung-Hoon Kim Source Type: research
Combination treatment of cordycepin and radiation induces MA-10 mouse Leydig tumor cell death via ROS accumulation and DNA damage
Am J Cancer Res. 2023 Apr 15;13(4):1329-1346. eCollection 2023.ABSTRACTLeydig cell tumor is the most frequent non-germ cell tumors of testis. The biggest challenge of using radiotherapy to treat testicular cancer is in effectively killing cancer cells and maintaining reproductive function after treatment. Our recently published article showed that cordycepin could enhance radiosensitivity to induce mouse Leydig tumor cell apoptosis by inducing cell cycle arrest, caspase pathway and endoplasmic reticulum (ER) stress. In the present study, the potency and mechanism of a previous combination treatment protocol on reactive oxy...
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Yi-Ping Lee Chin-Ru Lin Sih-Shang Chen Rong-Jane Chen Yuan-Hua Wu Ying-Hui Chen Bu-Miin Huang Source Type: research
Engineered lipid liquid crystalline nanoparticles as an inhaled nanoplatform for mucus penetration enhancement
In this study, a lipid liquid crystalline nanoparticle NLP@Z with surface zwitterion material hexadecyl betaine (HB) modification and N-acetylcysteine (NAC) encapsulation was presented to exert the combination strategy of mucus-inert surface and mucus degradation. The HB modification endowed NLP@Z mucus-inert surface to inhibit the interaction between NLP@Z and mucins, and the encapsulated NAC could effectively degrade the mucins and further decrease the mucus viscosity. This combination strategy was proved to significantly promote the mucus penetration performance and enhance epithelial cell uptake. In addition, the propo...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Wenhao Wang Jingxuan Zeng Peili Luo Jiayi Fang Qingao Pei Jinwu Yan Chune Zhu Wei Chen Yanyun Liu Zhengwei Huang Ying Huang Chuanbin Wu Xin Pan Source Type: research
N-Acetylcysteine May Regulate Altered Meteorin-Like Levels in Testicular Tissue due to Aluminum Exposure
This study aimed to determine whether NAC may reduce AL-induced oxidative stress, inflammation, and germ cell apoptosis in testicular tissues and its effects on meteorin-like (METRNL) levels, which are known to play a role in energy metabolism. In this experimental study, 28 Sprague-Dawley male rats were randomly divided into 4 groups (n = 7): control, AL (30 mg/kg/day AL), AL + NAC (30 mg/kg/day AL + 150 mg/kg/day NAC), and NAC (150 mg/kg/day NAC). All AL and NAC applications were performed intraperitoneally for 14 days. At the end of the experiment, the effects of AL and/or NAC applications on testicular tissue were exam...
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Tuba Yal çın Sercan Kaya Tuncay Kulo ğlu Ak ın Yiğin Source Type: research
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer
This study focused on Nrf2-mediated antioxidant systems in RES-treated lung cancer cells. A549 and H1299 cells were treated with various concentrations of RES at different times. RES decreased cell viability, inhibited cell proliferation, and increased the number of senescent and apoptotic cells in a concentration- and time-dependent manner. Moreover, RES-induced lung cancer cell arrest at the G1 phase was accompanied by changes in apoptotic proteins (Bax, Bcl-2, and cleaved caspase 3). Furthermore, RES induced a senescent phenotype along with changes in senescence-related markers (senescence-associated β-galactosidase ac...
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Chunhua Liang Kefan Yi Xu Zhou Xiaoting Li Caiyun Zhong Hui Cao Chunfeng Xie Jianyun Zhu Source Type: research
7,8-Diacetoxy-3-(4-methylsulfonylphenyl)-4-phenylcoumarin Induces ROS-dependent Cell Death in the A549 Human Lung Cancer Cell Line
CONCLUSION: The presence of 3-4-methylsulfonyl and 7,8-diacetoxy groups on 3,4-Diarylcoumarin is critical in modulating higher cytotoxic activity and could serve as a valuable template for the development of novel synthetic compounds as potential anticancer agents for lung cancer treatment.PMID:36854537 | DOI:10.21873/anticanres.16244
Source: Cell Research - February 28, 2023 Category: Cytology Authors: Musiliyu A Musa Qudus Kolawole Source Type: research
Dihydroartemisinin Induced Apoptosis and Synergized With Chemotherapy in Pleural Effusion Lymphoma Cells
CONCLUSION: DHA is a potentially effective candidate drug for PEL treatment.PMID:36854534 | DOI:10.21873/anticanres.16259
Source: Cell Research - February 28, 2023 Category: Cytology Authors: Ployploen Phikulsod Ryusho Kariya Jutatip Panaampon Seiji Okada Source Type: research
Artesunate Exhibits Synergy With Cisplatin and Cytotoxicity for Upper Tract and Bladder Urothelial Carcinoma Cells
CONCLUSION: ART may be a candidate drug for treating UTUC and bladder UC while increasing the therapeutic effect of cisplatin.PMID:36854526 | DOI:10.21873/anticanres.16263
Source: Cell Research - February 28, 2023 Category: Cytology Authors: San-Yuan Chen Chun-Nun Chao Hsin-Yi Huang Pei-Wen Zhao Chiung-Yao Fang Source Type: research
