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Molecules, Vol. 28, Pages 2844: Antileishmanial Activity of Cinnamic Acid Derivatives against Leishmania infantum
o de Sousa Leishmania infantum is the etiological agent of visceral leishmaniasis (VL) in South America, the Mediterranean basin, and West and Central Asia. The most affected country, Brazil, reported 4297 VL cases in 2017. L. infantum is transmitted by female phlebotomine sand flies during successive blood meals. There are no validated vaccines to prevent the infection and the treatment relies on drugs that often present severe side effects, which justify the efforts to find new antileishmanial drugs. Cinnamic acid derivatives have shown several pharmacological activities, including antiparasitic action. Therefore, in...
Source: Molecules - March 21, 2023 Category: Chemistry Authors: Mayara Castro de Morais Gisele Alves Medeiros Fernanda Silva Almeida Juliana da C âmara Rocha Yunierkis Perez-Castillo Tatjana de Souza Lima Keesen Dami ão Pergentino de Sousa Tags: Article Source Type: research

Molecules, Vol. 25, Pages 2928: Antifungal Agent 4-AN Changes the Genome-Wide Expression Profile, Downregulates Virulence-Associated Genes and Induces Necrosis in Candida albicans Cells
d Kubiński In the light of the increasing occurrence of antifungal resistance, there is an urgent need to search for new therapeutic strategies to overcome this phenomenon. One of the applied approaches is the synthesis of small-molecule compounds showing antifungal properties. Here we present a continuation of the research on the recently discovered anti-Candida albicans agent 4-AN. Using next generation sequencing and transcriptional analysis, we revealed that the treatment of C. albicans with 4-AN can change the expression profile of a large number of genes. The highest upregulation was observed in the case of gene...
Source: Molecules - June 24, 2020 Category: Chemistry Authors: Aleksandra Martyna Maciej Mas łyk Monika Janeczko El żbieta Kochanowicz Bart łomiej Gielniewski Aleksandra Świercz Oleg M. Demchuk Konrad Kubi ński Tags: Article Source Type: research

Molecules, Vol. 24, Pages 3216: Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies
astillo Leishmanicidal drugs have many side effects, and drug resistance to all of them has been documented. Therefore, the development of new drugs and the identification of novel therapeutic targets are urgently needed. Leishmania mexicana trypanothione reductase (LmTR), a NADPH-dependent flavoprotein oxidoreductase important to thiol metabolism, is essential for parasite viability. Its absence in the mammalian host makes this enzyme an attractive target for the development of new anti-Leishmania drugs. Herein, a tridimensional model of LmTR was constructed and the molecular docking of 20 molecules from a ZINC databa...
Source: Molecules - September 3, 2019 Category: Chemistry Authors: F élix Matadamas-Martínez Alicia Hern ández-Campos Alfredo T éllez-Valencia Alejandra V ázquez-Raygoza Sandra Compar án-Alarcón Lili án Yépez-Mulia Rafael Castillo Tags: Article Source Type: research