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Two Unique Mutations in HTRA1-Related Cerebral Small Vessel Disease in North America and Africa and Literature Review
To describe and compare two cases of North American and African patients who were diagnosed with HTRA1-related cerebral small vessel disease (CSVD) with homozygous and heterozygous mutations, respectively, in the linker domain of the HTRA1 gene.
Source: Journal of Stroke and Cerebrovascular Diseases - August 27, 2021 Category: Neurology Authors: Ty Shang, Marco Pinho, Debarti Ray, Alka Khera Tags: Case Report Source Type: research

Discovery of Anti-SS-A Antibodies during Stroke Investigations in Young Adults: What Impact?
Approximately 10 to 14% of ischemic strokes (IS) occur in young adults.1,2 It is a relatively rare event but several international studies have recently demonstrated a rising incidence in this population.3 –6 In the United States,4 the rate of strokes in the 35- to 39-year age group increased from 9.5 strokes per 100,000 person-years in 1995–1999 to 23.6 strokes per 100,000 person-years in 2010–2014 (risk ratio 2.47; 95% CI, 2.07–2.96 [p 
Source: Journal of Stroke and Cerebrovascular Diseases - June 15, 2021 Category: Neurology Authors: Soledad Henriquez, Nicolas Legris, Pascale Chr étien, Salima Hacein-Bey-Abina, Julien Henry, Christian Denier, Nicolas Noël Source Type: research

Program to Avoid Cerebrovascular Events through Systematic Electronic Tracking and Tailoring of an Eminent Risk factor: Protocol of a RCT
Geographical and racial disparities in stroke outcomes are especially prominent in the Southeastern United States, which represents a region more heavily burdened with stroke compared to the rest of the country. While stroke is eminently preventable, particularly via blood pressure control, fewer than one third of patients with a stroke have their blood pressure controlled ≥ 75% of the time, and low consistency of blood pressure control is linked to higher stroke risk.
Source: Journal of Stroke and Cerebrovascular Diseases - May 27, 2021 Category: Neurology Authors: Ashley M. Wabnitz, Jessica Chandler, Frank Treiber, Souvik Sen, Carolyn Jenkins, Jill C. Newman, Martina Mueller, Ariana Tinker, Amelia Flynn, Raelle Tagge, Bruce Ovbiagele Source Type: research

Outcomes of Homeless Ischemic Stroke Patients Receiving Intravenous Thrombolysis in the United States
Morbidity and mortality among homeless people with cardiovascular diseases and stroke in the United States is high. Adverse outcomes within the homeless population may be the result of seeking care too late to receive time-sensitive interventions. We sought to investigate the impact of homelessness on ischemic stroke patients who received intravenous thrombolysis (IVT).
Source: Journal of Stroke and Cerebrovascular Diseases - May 22, 2021 Category: Neurology Authors: Ganesh Asaithambi, Emily H. Marino, Bridget M. Ho, Megan E. Tipps Source Type: research

Racial Disparities in Ischemic Stroke among Patients with COVID-19 in the United States
Cerebrovascular prevalence is high in patients with coronavirus disease 2019 (COVID-19). However, whether racial disparities exist among this population have not been systematically explored.
Source: Journal of Stroke and Cerebrovascular Diseases - May 18, 2021 Category: Neurology Authors: Alain Lekoubou, Matt Pelton, Djibril M. Ba, Addy Ssentongo Source Type: research

Predictive Factors of Perioperative Stroke-Related Mortality Following Vascular Surgery: A Retrospective Analysis
Strokes are one of the leading causes of death in the United States. With 90% of strokes being attributed to modifiable risk factors, an opportunity arises to decrease the overall burden of strokes on the healthcare system.1 Perioperative stroke, defined as a stroke taking place during or within 30 days of a surgical procedure, is an uncommon, yet devastating outcome that is linked to significant morbidity and mortality.2 –6 Vascular surgical procedures carry a higher risk of perioperative stroke and stroke-related mortality, yet the independent risk factors contributing to this increased mortality have not been described.
Source: Journal of Stroke and Cerebrovascular Diseases - May 5, 2021 Category: Neurology Authors: Bansri M. Patel, Nathan J. Reinert, Natalie D. Sridharan, Parthasarathy D. Thirumala Source Type: research

Effect of Insurance Status on Outcomes of Acute Ischemic Stroke Patients Receiving Intra-Arterial Treatment: Results from the Paul Coverdell National Acute Stroke Program
Stroke continues to be a leading cause of death and disability in the United States. Rates of intra-arterial reperfusion treatments (IAT) for acute ischemic stroke (AIS) are increasing, and these treatments are associated with more favorable outcomes. We sought to examine the effect of insurance status on outcomes for AIS patients receiving IAT within a multistate stroke registry.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2021 Category: Neurology Authors: Ganesh Asaithambi, Xin Tong, Kamakshi Lakshminarayan, Sallyann M Coleman King, Mary G George Source Type: research

Corrigendum to ‘Health Behaviors among Stroke Survivors in the United States: A Propensity Score-Matched Study’ Journal of Stroke & Cerebrovascular Diseases, Vol. 27, No. 8 (August), 2018: pp 2124 –2133
The authors regret to inform the readers that there was an unnoticed mistake in the paper. An affiliation of Dr. Wali was not listed at the time of publication due to an oversight from the author. The aforementioned missing affiliation is the following: Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2021 Category: Neurology Authors: Haytham Wali, Sawsan Kurdi, Jawad Bilal, Irbaz Bin Riaz, Sandipan Bhattacharjee Tags: Corrigendum Source Type: research

Impact of the COVID-19 pandemic on stroke epidemiology and clinical stroke practice in the US
: To examine the impact of the COVID-19 pandemic on stroke, the number of stroke patients, time since last known well (LKW), morbidity, and mortality of stroke patients in Southwest Healthcare System (SHS), California (CA) and the United States (US) were analyzed during 2019 and compared to 2020. Our hypothesis is that there are regional differences in stroke outcome depending on location during the COVID-19 study period which influences stroke epidemiology and clinical stroke practice.
Source: Journal of Stroke and Cerebrovascular Diseases - January 26, 2021 Category: Neurology Authors: Daniel Friedlich, Tali Newman, Stephanie Bricker Source Type: research

The Joint Association of Septicemia and Cerebrovascular Diseases with In-Hospital MortalityAmong Patients with Left Ventricular Assist Device in the United States
Currently, about 6.2 million adults in the US are reported to have heart failure, and this prevalence is expected to increase by 46% by 2030.1 The prognosis of advanced heart failure especially, advanced systolic heart failure, has improved tremendously with the advent of implantable mechanical circulatory support devices such as left ventricular assist device (LVAD) which is often used as a bridge to heart transplantation or as a destination therapy.2,3 Indeed, LVAD has improved the 1-year survival of patients with advanced heart disease from 52% to about 85%.
Source: Journal of Stroke and Cerebrovascular Diseases - January 19, 2021 Category: Neurology Authors: Jessica Lovelace, Obadeh Shabaneh, Noah De La Cruz, Damilola R. Owoade, Chike C. Nwabuo, Nandini Nair, Duke Appiah Source Type: research

Patient Characteristics and Outcomes Associated with Decline in Stroke Volumes during the Early COVID-19 Pandemic
Recent studies have documented a decrease in evaluations of stroke patients during the early weeks of the coronavirus disease 2019 (COVID-19) outbreak in the United States (US).1 –4 This phenomenon raises concern that delays in emergent treatment and implementation of secondary stroke prevention measures may contribute to the morbidity and mortality of the pandemic. As a second wave of COVID-19 sweeps through the country, there is an urgent need for public health communica tion that targets populations most likely to delay evaluation for stroke-like symptoms.
Source: Journal of Stroke and Cerebrovascular Diseases - December 25, 2020 Category: Neurology Authors: Adam N. Wallace, Kaiz S. Asif, Daniel H. Sahlein, Steven J. Warach, Timothy Malisch, E. Francis LaFranchise, Scott Geraghty, K. Derek Kreitel, Marian P. Lamonte, Jefferson T. Miley, Daniel P. Gibson, Krishna Amuluru Source Type: research

Impact of COVID-19 on Outcomes in Ischemic Stroke Patients in the United States
Studies have shown worse outcomes in patients with comorbid ischemic stroke (IS) and coronavirus disease 2019 (COVID-19), but have had small sample sizes.
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2020 Category: Neurology Authors: Adam de Havenon, John P. Ney, Brian Callaghan, Alen Delic, Samuel Hohmann, Ernie Shippey, Gregory J. Esper, Eric Stulberg, David Tirschwell, Jennifer Frontera, Shadi Yaghi, Mohammad Anadani, Jennifer J. Majersik Source Type: research

Endovascular Treatment Decision Making in Patients with Low Baseline ASPECTS: Insights from UNMASK EVT, an International Multidisciplinary Study
Endovascular therapy is a highly effective treatment for acute ischemic stroke (AIS) due to large vessel occlusion (LVO)1 and now considered standard of care.2 In most randomized EVT trials, patients with low Alberta Stroke Program Early CT Score (ASPECTS) scores were either excluded or underrepresented. Hence, current European and North American guidelines for the early management of patients with acute ischemic stroke restrict level 1A recommendations for endovascular therapy (EVT) to patients with baseline ASPECTS score>5.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Johanna Maria Ospel, Ravinder Singh, Nima Kashani, Mohammed Almekhlafi, Alexis Wilson, Urs Fischer, Bruce Campbell, Shinichi Yoshimura, Francis Turjman, Pillai Sylaja, Ji-Hoe Heo, Michael D. Hill, Gustavo Saposnik, Mayank Goyal, Bijoy Menon Source Type: research

Disease Burden Following Non-Cardioembolic Minor Ischemic Stroke or High-Risk TIA: A GWTG-Stroke Study
We examined outcomes and Medicare payments following any severity IS or TIA as well as the subgroup with minor IS or high-risk TIA.
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2020 Category: Neurology Authors: Brystana G. Kaufman, Shreyansh Shah, Anne S. Hellkamp, Barbara L. Lytle, Gregg C. Fonarow, Lee H. Schwamm, Eva Les én, Jonatan Hedberg, Amarjeet Tank, Edmond Fita, Narinder Bhalla, Nipun Atreja, Janet Prvu Bettger Source Type: research

Timing of Recognition for Perioperative Strokes Following Cardiac Surgery
Cerebrovascular disease represents one of the largest burdens to mortality, morbidity, and healthcare associated costs both in the United States and globally.1 –3 While prevention should be the primary strategy especially in patients with stroke risk factors, early recognition of strokes provides opportunity for revascularization that limits morbidity and mortality.4 Paradoxically, strokes that occur during hospitalizations have been shown to result in l ower rates of early detection, increased wait times to intervention, and poorer overall outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2020 Category: Neurology Authors: Beret Amundson, Joseph Hormes, Anna Katema, Priyadharshi Rathakrishnan, J. Kirk Edwards, Gregory Esper, Jose Binongo, Yi Lasanajak, Brent Keeling, Michael Halkos, Fadi Nahab Source Type: research

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