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Outcomes among patients with primary angiitis of the CNS: A Nationwide United States analysis
Primary angiitis of the central nervous system (PACNS) is a relapsing-remitting disease with a heterogeneous course. Case series have delineated the long-term disease course but not acute outcomes or their determinants. The national United States hospital burden of PACNS has not been quantified.
Source: Journal of Stroke and Cerebrovascular Diseases - September 23, 2022 Category: Neurology Authors: Smit D. Patel, Fadar Otite Oliver, Ahmed Elmashad, Neel Patel, Tapan Mehta, Jason Hinman, David S. Liebeskind, Aneesh B. Singhal, Anne Ducros, Jeffrey L. Saver Source Type: research

Trends in admissions for intracranial dissections in the United States
Intracranial artery dissection (IAD) is rarer than cervical artery dissections (CeAD), and information is based on limited series with small cohorts. There are only several small-scale studies attempting to characterize the natural history of the disease. Herein, we analyze the prevalence of IADs in hospitalized patients using a national database.
Source: Journal of Stroke and Cerebrovascular Diseases - September 16, 2022 Category: Neurology Authors: Waseem Wahood, Giuseppe Lanzino, Zafer Keser Source Type: research

Evaluation of the Rapid Arterial oCclusion Evaluation (RACE) scale in Upstate South Carolina, USA
This study was designed to determine if the Rapid Arterial oCclusion Evaluation scale is a valid prehospital stroke assessment for identifying large vessel occlusion patients in South Carolina, USA.
Source: Journal of Stroke and Cerebrovascular Diseases - September 8, 2022 Category: Neurology Authors: Samadhi Thavarajah, Zachary Langston, Adam Sarayusa, Lauren A. Fowler, Sanjeev Sivakumar, Neel Shah Source Type: research

Trends in post-discharge prophylactic anticoagulant use among stroke patients in the United States between 2006 and 2019
Stroke is an independent risk factor for venous thromboembolism (VTE). Although the risk of VTE persists after hospital discharge, information on the utilization of anticoagulants among stroke patients after discharge remains limited.
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2022 Category: Neurology Authors: Ghadeer K. Dawwas, Adam Cuker, Aaron Rothstein, Sean Hennessy Source Type: research

Variability in Intensive Care Utilization for Intracerebral Hemorrhage in the United States: Retrospective Cohort Study
We examined whether ICU availability was a significant contributor to ICH outcomes by US geographic region.
Source: Journal of Stroke and Cerebrovascular Diseases - July 1, 2022 Category: Neurology Authors: David Daniel, Daniel Santos, Luke Maillie, Mandip S. Dhamoon Source Type: research

Functional Recovery in Patients with Acute Stroke and Pre-Existing Disability: A Natural History Study
One million strokes occur in the United States every year, with as many as 1 in 3 occurring among patients with a pre-existing disability.1,2 Though they are a significant portion of the stroke population, such patients are often excluded from interventional trials.3-5 As a result, acute ischemic stroke patients with pre-morbid disability are often omitted from clinical practice treatment guidelines, such as for mechanical thrombectomy (MT). In the latest American Heart Association (AHA) guidelines, MT is only indicated for patients with no pre-stroke disability, as defined by a modified Rankin scale (mRS) score of 0-1.
Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2022 Category: Neurology Authors: Nicholas Vigilante, Scott Kamen, Ryan Shannon, Lauren Thau, Miriam Butler, Solomon Oak, Linda Zhang, Taryn Hester, Jesse M. Thon, James E. Siegler Source Type: research

Vascular Risk Factor Prevalence and Trends in Native Americans with Ischemic Stroke
Native Americans have a higher incidence and prevalence of stroke and the highest stroke-related mortality among race-ethnic groups in the United States. We aimed to analyze trends in the ischemic stroke (IS) vascular risk factor prevalence in Native Americans along with a comparison to the other race-ethnic groups.
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2022 Category: Neurology Authors: Dinesh V. Jillella, Sara Crawford, Rocio Lopez, Atif Zafar, Anne S. Tang, Ken Uchino Source Type: research

Quality of Care and Outcomes for Patients with Acute Ischemic Stroke and Transient Ischemic Attack During the COVID-19 Pandemic
Hospitalizations for acute ischemic stroke (AIS) and transient ischemic attack (TIA) decreased during the COVID-19 pandemic. We compared the quality of care and outcomes for patients with AIS/TIA before vs. during the COVID-19 pandemic across the United States Department of Veterans Affairs healthcare system.
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2022 Category: Neurology Authors: Laura J. Myers, Anthony J. Perkins, Monique F. Kilkenny, Dawn M. Bravata Source Type: research

Educational Intervention in the Emergency Department to Address Disparities in Stroke Knowledge
In the United States, Black individuals have higher stroke incidence and mortality when compared to white individuals and are also at risk of having lower stroke knowledge and awareness. With the need to implement focused interventions to decrease stroke disparities, the objective of this study is to evaluate the feasibility and efficacy of an emergency department-based educational intervention aimed at increasing stroke awareness and preparedness among a disproportionately high-risk group.
Source: Journal of Stroke and Cerebrovascular Diseases - March 22, 2022 Category: Neurology Authors: Erin F. Shufflebarger, Lauren A. Walter, Toby I. Gropen, Tracy E. Madsen, Mark R. Harrigan, Ronald M. Lazar, Jamie Bice, Cassidy S. Baldwin, Michael J. Lyerly Source Type: research

Endovascular Therapy is Effective for Large Vessel Occlusion Despite Concurrent Cancer
Ischemic stroke and concurrent cancer is increasingly recognized. However, optimal management is uncertain. As mechanical thrombectomy has become the standard of care for large vessel occlusion, more patients with cancer are presenting for embolectomy. However, it is unknown whether this subgroup has the same benefit profile described in multiple randomized trials for thrombectomy for large vessel occlusion. Our objective was to retrospectively evaluate a North American embolectomy database for safety and outcomes in patients with active cancer.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2022 Category: Neurology Authors: Thomas K. Mattingly, Jorge E. Risco, Jaclyn E. Burch, Raquel Whyte, Gurkirat S. Kohli, Stephen Susa, Tarun Bhalla, Matthew T. Bender Source Type: research

Annual Direct Cost of Dysphagia Associated with Acute Ischemic Stroke in the United States
Dysphagia after acute ischemic stroke is frequent and increases the risk of pneumonia, insertion of feeding tube, hospital length-of-stay and rates of discharge to institutional care. However, the financial impact of dysphagia after acute ischemic stroke is not well understood.
Source: Journal of Stroke and Cerebrovascular Diseases - March 5, 2022 Category: Neurology Authors: Adnan I. Qureshi, M. Fareed K. Suri, Wei Huang, Yasemin Akinci, Mohammad R. Chaudhry, Donna S. Pond, Brandi R. French, Farhan Siddiq, Camilo R. Gomez Source Type: research

Global Metabolomic Profiling Reveals Disrupted Lipid and Amino Acid Metabolism Between the Acute and Chronic Stages of Ischemic Stroke
Stroke is a major cause of serious disability in the United States. Previous studies found multiple associations of serum metabolites with acute ischemic stroke (AIS) compared to controls, but few of them evaluated metabolome in a longitudinal fashion. Therefore, we compared the metabolome of the acute and chronic stages of ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 29, 2022 Category: Neurology Authors: Evgeny V. Sidorov, Chao Xu, Jonathan Garcia-Ramiu, Apple Blair, Jorge Ortiz-Garcia, David Gordon, Juliane Chainakul, Dharambir K. Sanghera Source Type: research

An observational epidemiological study to analyze intracerebral hemorrhage across the United States: Incidence and mortality trends from 1990 to 2017
Intracerebral Hemorrhage (ICH) accounts for 10% of strokes annually in the United States (US). Up-to-date trends in disease burden and regional variations remain unknown. Our study reports updated trends of ICH incidence, mortality, and mortality to incidence ratio (MIR) across the US.
Source: Journal of Stroke and Cerebrovascular Diseases - January 25, 2022 Category: Neurology Authors: Augustin J. DeLago, Harpreet Singh, Chinmay Jani, Arashdeep Rupal, Joseph Shalhoub, Richard Goodall, Darshil Shah, Adam Hartley, Matthew Hammond-Haley, Dominic C. Marshall, Martin Gizzi, Mahmood AbdelRazek, Justin D. Salciccioli Source Type: research

Trends in Prevalence of Serious Psychological Distress and Depression Among Adults with Stroke in the United States
To examine national trends in prevalence of serious psychological distress and depression among adults with stroke in the United States (US) from 2004 to 2017, and variations across sociodemographic subgroups.
Source: Journal of Stroke and Cerebrovascular Diseases - December 27, 2021 Category: Neurology Authors: Liming Dong, Briana Mezuk, Lynda D. Lisabeth Source Type: research

Association Between Dispatch Complaint and Critical Prehospital Time Intervals in Suspected Stroke 911 Activations in the National Emergency Medical Services Information System, 2012 –2016
Stroke, one of the leading causes of death and disability in the United States (US), is a time sensitive emergency.1 Receiving timely treatment is associated with increased survival and better outcomes.2 –5 For every minute that treatment is delayed, a patient with stroke may lose an estimated 1.9 million neurons, leading to irreversible brain tissue damage long term disability, or death.6 Several studies have demonstrated that treatment with intravenous recombinant tissue-type plasminogen activat or (IV alteplase) can positively affect clinical outcomes when administered within a critical timeframe after ischemic stroke symptom onset.
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2021 Category: Neurology Authors: Amena Y. Abbas, Erika C. Odom, Isaac Nwaise Source Type: research

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