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Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States
This study aimed to determine the association between the Danish Co-morbidity Index for Acute Myocardial Infarction (DANCAMI) and restricted DANCAMI (rDANCAMI) scores and clinical outcomes in patients hospitalized with AMI. Using the National Inpatient Sample, all AMI hospitalizations were stratified into four groups based on their DANCAMI and rDANCAMI score (0; 1 to 3; 4 to 5; ≥6). The primary outcome was all-cause mortality, whereas secondary outcomes were major adverse cardiovascular/cerebrovascular events, major bleeding, ischemic stroke, and receipt of coronary angiography or percutaneous coronary intervention.
Source: The American Journal of Cardiology - July 14, 2022 Category: Cardiology Authors: Balamrit Singh Sokhal, Andrija Mateti ć, Abhishek, Philip Freeman, Jan Walter Dhillon Shanmuganathan, Mohamed O. Mohamed, Christian Mallen, Mamas A. Mamas Source Type: research

Age-Related Disparity Trends in Stroke-Related Mortality in the United States, 1999 to 2019
Stroke hospitalizations and mortality have declined in older subjects in the United States; however, acute ischemic stroke hospitalizations have increased in subjects 25 to 64  years of age.1,2 Regardless of increasing acute ischemic stroke hospitalization trends in young patients, population-based estimates and trends of stroke (including hemorrhagic and ischemic stroke) related mortality stratified by age groups are currently scarce. Therefore, in this study, we assess ed trends in stroke mortality rates in varying age groups over 2 decades in the United States.
Source: The American Journal of Cardiology - February 28, 2022 Category: Cardiology Authors: Rochell Issa, Abdul Mannan Khan Minhas, Robert W. Ariss, Salik Nazir, Hiba Rehman, Waleed Tallat Kayani, Salim S. Virani Source Type: research

Meta-Analysis of Racial Disparity in Utilization of Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia in the United States (US), and is associated with a substantial increase in the risk of ischemic stroke. Although prevalence of AF is lower in black individuals, they face a higher risk of stroke compared with patients of white race.1 Oral anticoagulant (OAC) therapy is the stroke prevention strategy in high-risk patients with AF. Despite the higher burden of ischemic stroke in Black AF patients, some studies suggest lower utilization of OAC among them.
Source: The American Journal of Cardiology - June 17, 2021 Category: Cardiology Authors: Izza Shahid, Muhammad Shariq Usman, Tariq Jamal Siddiqi, Faiza Zakaria, Mohamad Alkhouli Source Type: research

Atrial Septal Defect and the Risk of Ischemic Stroke in the Perioperative Period of Noncardiac Surgery
Stroke is a serious complication of non-cardiac surgery. Congenital defects of the interatrial septum may be a potent risk factor for perioperative stroke. The aim of the present study was to determine the association between atrial septal defect (ASD) or patent foramen ovale (PFO) and in-hospital perioperative ischemic stroke after non-cardiac surgery in a large nationwide cohort of patients hospitalized in the United States. Patients undergoing noncardiac surgery between 2004 and 2014 were identified using the Healthcare Cost and Utilization Project's National Inpatient Sample.
Source: The American Journal of Cardiology - July 14, 2019 Category: Cardiology Authors: Nathaniel R. Smilowitz, Varun Subashchandran, Jeffrey S. Berger Source Type: research

Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (From the REasons for Geographic and Racial Differences in Stroke Study)
Cardiovascular disease is a leading cause of death. Proneurotensin is a biomarker associated with the development of cardiovascular disease, cardiovascular mortality, and all-cause mortality. We assessed the association of fasting proneurotensin with mortal events by sex and race (black-white) in a United States (US) population. Using a case-cohort sub-population of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, fasting proneurotensin was measured on a 1046-person subcohort and 651 participants with incident coronary heart disease (CHD).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Nicholas Wettersten, Mary Cushman, Virginia J. Howard, Oliver Hartmann, Gerasimos Filippatos, Neil Beri, Paul Clopton, George Howard, Monika M. Safford, Suzanne E. Judd, Andreas Bergmann, Joachim Struck, Alan Maisel Source Type: research

Comparison of Risk of Atrial Fibrillation among Employed Versus Unemployed (From the REasons for Geographic and Racial Differences in Stroke Study)
Involuntary unemployment due to job loss has been associated with increased risk of cardiovascular events. Whether it also is associated with increased risk of atrial fibrillation (AF) is currently unknown. Therefore, we examined this association in 8,812 participants residing mainly in the Southeastern United States (mean age 58.1 ± 7.8 years; 63.2%; women; 43.2% black) with data on employment status who were enrolled in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study between 2003 and 2007 after excluding those with voluntary unemployment (e.g.
Source: The American Journal of Cardiology - July 21, 2017 Category: Cardiology Authors: Elsayed Z. Soliman, Zhu-Ming Zhang, Suzanne Judd, Virginia J. Howard, George Howard Source Type: research