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Comparative study of on-label versus off-label treatment of intracranial aneurysms with the Pipeline embolization device
CONCLUSIONS: In real-world practice, off-label use of PED is common and can achieve similar efficacy as on-label use. However, in aggregate, off-label use was found to carry an increased rate of ischemic complications. With judicious attention to safety and individual patient characteristics, these results highlight the scale and general feasibility of off-label PED use by experts.PMID:35090133 | DOI:10.3171/2021.11.JNS212481
Source: Journal of Neurosurgery - January 28, 2022 Category: Neurosurgery Authors: Samuel J Cler David C Lauzier Arindam R Chatterjee Joshua W Osbun Christopher J Moran Akash P Kansagra Source Type: research

E-117 Evaluation of patient deaths after mechanical thrombectomy - A single center experience
ConclusionApproximately 50% of patients who died after mechanical thrombectomy died due to non-neurological causes.Disclosures A. Kuhn: None. V. Naragum: None. R. Catton: None. J. Singh: None. F. Massari: None. K. de Macedo Rodrigues: None. M. Gounis: 1; C; National Institutes of Health (NIH), the United States – Israel Binational Science Foundation, Anaconda, ApicBio, Axovant, Cerenovus, Cook Medical, Gentuity, Imperative Care, InNeuroCo, Magneto. 2; C; Cerenovus, Imperative Care, phenox, Medtronic Neurovascular, Route 92 Medical, Stryker Neurovascular. 4; C; Imperative Care, InNeuroCo and Neurogami. A. Puri: 1; C; ...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Kuhn, A., Naragum, V., Catton, R., Singh, J., Massari, F., de Macedo Rodrigues, K., Gounis, M., Puri, A. Tags: Electronic poster abstracts Source Type: research

O-005 Comparison of on-label versus off-label treatment of intracranial aneurysms with the pipeline embolization devices
ConclusionIn real-world practice, off-label uses of PED can achieve similar safety and efficacy to on-label uses, though there may be a slightly higher rate of ischemic complications in off-label uses. Expert judgment is a useful supplement to official guidelines when assessing reasonable PED use beyond its approved indications.Disclosures S. Cler: None. D. Lauzier: None. A. Kansagra: 2; C; Penumbra, Microvention, iSchemaView.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Cler, S., Lauzier, D., Kansagra, A. Tags: Oral abstracts Source Type: research

Characteristics and career outcomes of Neurosurgery Research and Education Foundation research fellowship recipients.
CONCLUSIONSThe majority of AANS/NREF research award recipients enter academics as fellowship-trained neurosurgeons, with approximately one-third obtaining NIH funding. Analysis of this unique cohort allows for identification of characteristics of academic success. PMID: 30738408 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 8, 2019 Category: Neurosurgery Authors: Wilson TA, Langston RG, Wong KH, Rodriguez A Tags: J Neurosurg Source Type: research