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Ocular and systemic determinants of perifoveal and macular vessel parameters in healthy African Americans
CONCLUSIONS: When interpreting OCTA images in a clinical setting, it is important to consider the effects ocular and systemic characteristics may have on the macular microcirculation.PMID:34740885 | DOI:10.1136/bjophthalmol-2021-319675
Source: The British Journal of Ophthalmology - November 6, 2021 Category: Opthalmology Authors: Grace M Richter Jae Chang Lee Nasir Khan Alexander Vorperian Brennan Hand Bruce Burkemper Xiao Zhou Zhongdi Chu Ruikang Wang Rohit Varma Amir H Kashani Source Type: research

Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank
CONCLUSIONS: AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.PMID:34518160 | DOI:10.1136/bjophthalmol-2021-319508
Source: The British Journal of Ophthalmology - September 14, 2021 Category: Opthalmology Authors: Xianwen Shang Zhuoting Zhu Yu Huang Xueli Zhang Wei Wang Danli Shi Yu Jiang Xiaohong Yang Mingguang He Source Type: research

Cardiovascular risk in patients receiving ranibizumab for exudative age-related macular degeneration: a nationwide self-controlled case-series study.
CONCLUSIONS: Ranibizumab intravitreal injections did not increase the overall risk of stroke or AMI. Although the cardiovascular risk in patient receiving ranibizumab seems to be low, continuous monthly use of ranibizumab for high-risk patients should be judged carefully. PMID: 32522792 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - June 9, 2020 Category: Opthalmology Authors: Jeon HL, Byun SJ, Pratt NL, Sultana J, Park SJ, Shin JY Tags: Br J Ophthalmol Source Type: research

Controversies on neuroprotection therapy in non-arteritic anterior ischaemic optic neuropathy.
CONCLUSIONS: Unfortunately, in spite of all the experimental and clinical research on neuroprotection agents in NA-AION so far, we have no scientifically proven evidence of neuroprotection agents showing any benefit in the human clinical studies so far. PMID: 31488431 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - September 4, 2019 Category: Opthalmology Authors: Hayreh SS Tags: Br J Ophthalmol Source Type: research

Safety of 5914 intravitreal ziv-aflibercept injections.
CONCLUSION: This constitutes the largest pooled safety report on IVZ use and includes patients from 14 centres distributed across the globe. It shows that IVZ has an acceptable ocular and systemic safety profile with incidences of adverse events similar to those of other vascular endothelial growth factor inhibitory drugs. The analysis supports the continued use of IVZ in various retinal disorders. PMID: 30099379 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - August 11, 2018 Category: Opthalmology Authors: Singh SR, Stewart MW, Chattannavar G, Ashraf M, Souka A, ElDardeery M, Wadhwa N, Sarvaiya C, Mansour AM, Marashi A, Ramchandani S, Braimah IZ, Jabbarpoor Bonyadi MH, Ramezani A, Soheilian M, de Oliveira Dias JR, de Andrade GC, Maia A, Rodrigues EB, Farah Tags: Br J Ophthalmol Source Type: research

Increased stroke risk among patients with open-angle glaucoma: a 10-year follow-up cohort study.
CONCLUSIONS: Patients who were diagnosed with OAG were more likely to experience subsequent stroke than comparison group without OAG, and the risk was greater for older adults and males. PMID: 28729368 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - July 20, 2017 Category: Opthalmology Authors: Rim TH, Lee SY, Bae HW, Kim SS, Kim CY Tags: Br J Ophthalmol Source Type: research

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