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Near-Infrared Autofluorescence in Atherosclerosis Associates With Ceroid and Is Generated by Oxidized Lipid-Induced Oxidative Stress
CONCLUSIONS: In human atherosclerosis and human macrophages in vitro, NIRAF colocalizes with lipid and specifically insoluble lipid or ceroid. In vitro studies further show that oxidized LDL generates NIRAF, oxidative stress, and lipid peroxidation products. These results demonstrate a new pathway for NIRAF generation through oxidized lipid-driven oxidative stress and support ceroid as a source of NIRAF in human atherosclerosis. These findings may inform future clinical intracoronary NIRAF imaging studies of patients with coronary artery disease.PMID:34011166 | DOI:10.1161/ATVBAHA.120.315612
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 20, 2021 Category: Cardiology Authors: Mazen S Albaghdadi Ryutaro Ikegami Mohamad B Kassab Joseph A Gardecki Mie Kunio Mohammed M Chowdhury Ramzi Khamis Peter Libby Guillermo J Tearney Farouc A Jaffer Source Type: research
