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Multilocus analysis of the association of polymorphic variants of inflammation genes with ischemic stroke in Russians.
Abstract Carriage frequencies of alleles and genotypes of polymorphic loci of inflammation genes (49A>G CTLA4, 41G>A and 87C>T PDE4D, -590C>T IL4, -308A>G TNF, 252G>A LTA, 874A>T IFNG, -509С>Т, 869T>C and 915G>C TGFB1) were determined in a sample of 200 patients diagnosed with ischemic stroke and in the control group similar in gender and age (146 individuals), all ethnic Russians. The positive association of the allele PDE4D*87C (р = 0.028) and genotype TGFB1*-509Т/Т (р = 0.02) carriage with ischemic stroke was shown. The association of the disease with the carriage of the alle...
Source: Molekuliarnaia Biologiia - June 30, 2016 Category: Molecular Biology Authors: Titov BV, Matveeva NA, Martynov MY, Favorova OO Tags: Mol Biol (Mosk) Source Type: research

Possible synergistic effect of apoE and LRP1 genotypes on metabolic syndrome development in Serbian patients.
Abstract The modern way of life contributes to the higher frequency of a complex state medically called metabolic syndrome (MetS), which is an inevitable consequence of several most common diseases of modern civilization. Patients with MetS have three times higher risk of experiencing a heart attack or a stroke and twice higher possibility to die from them. Serbia holds the infamous third place in Europe in mortality from heart disease, just behind Russia and Ukraine. The study explores the correlation of every combination of genotypes of apoE (apolipoprotein E) and LRP1 (low density receptor- related protein 1) g...
Source: Molecular Biology Reports - September 19, 2019 Category: Molecular Biology Authors: Vučinić N, Stankov K, Đan M, Barjaktarović I, Stokić E, Strajnić LJ, Obreht D, Đan I Tags: Mol Biol Rep Source Type: research