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Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis using Iron Oxide Particles and MRI.
CONCLUSIONS: These functional molecular MRI probes constitute a novel imaging tool for ex vivo characterization of atherosclerosis at a molecular level. Further development and translation into the clinical arena will facilitate more accurate risk stratification in carotid artery disease in the future. PMID: 24594295 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - March 1, 2014 Category: Surgery Authors: Chan JM, Monaco C, Wylezinska-Arridge M, Tremoleda JL, Gibbs RG Tags: Eur J Vasc Endovasc Surg Source Type: research

Imaging of the Vulnerable Carotid Plaque: Biological Targeting of Inflammation in Atherosclerosis using Iron Oxide Particles and MRI
This study aims at visualizing and characterizing atherosclerosis using antibody-conjugated superparamagnetic iron oxide (SPIO) particles as an MRI probe to assess inflammation in human atherosclerotic plaques.Methods: Atherosclerotic plaques were collected from 20 consecutive patients (n = 10 from symptomatic patients, n = 10 from asymptomatic patients) undergoing carotid endarterectomy (CEA) for extracranial high-grade internal carotid artery (ICA) stenosis (>70% luminal narrowing). Inflammatory markers on human atherosclerotic plaques were detected and characterized by ex vivo magnetic resonance imaging (MRI) using...
Source: European Journal of Vascular and Endovascular Surgery - March 3, 2014 Category: Surgery Authors: J.M.S. Chan, C. Monaco, M. Wylezinska-Arridge, J.L. Tremoleda, R.G.J. Gibbs Tags: Carotid Disease Source Type: research