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Source: Human Brain Mapping
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Assessing neuronal density in peri ‐infarct cortex with PET: Effects of cortical topology and partial volume correction
Abstract
The peri‐infarct cortex (PIC) is the site of long‐term physiologic changes after ischemic stroke. Traditional methods for delineating the peri‐infarct gray matter (GM) have used a volumetric Euclidean distance metric to define its extent around the infarct. This metric has limitations in the case of cortical stroke, i.e., those where ischemia leads to infarction in the cortical GM, because the vascularization of the cerebral cortex follows the complex, folded topology of the cortical surface. Instead, we used a geodesic distance metric along the cortical surface to subdivide the PIC into equidistant rings em...
Source: Human Brain Mapping - September 10, 2016 Category: Neurology Authors: Thomas Funck, Mohammed Al ‐Kuwaiti, Claude Lepage, Peter Zepper, Jeffrey Minuk, Hyman M. Schipper, Alan C. Evans, Alexander Thiel Tags: Research Article Source Type: research
