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Drug: Temodar
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Total 7 results found since Jan 2013.
Regulatory Issues: PMDA - Review of Sakigake Designation Products: Oncolytic Virus Therapy with Delytact Injection (Teserpaturev) for Malignant Glioma
Oncologist. 2023 Mar 14:oyad041. doi: 10.1093/oncolo/oyad041. Online ahead of print.ABSTRACTIn June 2021, the Ministry of Health, Labor and Welfare approved Delytact Injection as a regenerative medical product for oncolytic virus therapy. The active substance of Delytact Injection is teserpaturev, a genetically engineered herpes simplex virus type 1 (strain F) in which the α47 gene and both copies of the γ34.5 gene have been deleted and the infected cell protein 6 (ICP6) gene has been inactivated by the insertion of the lacZ gene from Escherichia coli. Delytact Injection, when intratumorally administered to patients with...
Source: The Oncologist - March 14, 2023 Category: Cancer & Oncology Authors: Yoshiaki Maruyama Akira Sakurai Shinichi Noda Yasuhiro Fujiwara Narumi Okura Toshinori Takagi Junichi Asano Futaba Honda Source Type: research
Intratumoral oncolytic herpes virus G47 ∆ for residual or recurrent glioblastoma: a phase 2 trial
This study showed a survival benefit and good safety profile, which led to the approval of G47∆ as the first oncolytic virus product in Japan.PMID:35864254 | DOI:10.1038/s41591-022-01897-x
Source: Herpes - July 21, 2022 Category: Infectious Diseases Authors: Tomoki Todo Hirotaka Ito Yasushi Ino Hiroshi Ohtsu Yasunori Ota Junji Shibahara Minoru Tanaka Source Type: research
A phase I/II study of triple-mutated oncolytic herpes virus G47 ∆ in patients with progressive glioblastoma
This study shows that G47Δ is safe for treating recurrent/progressive glioblastoma and warrants further clinical development.PMID:35864115 | DOI:10.1038/s41467-022-31262-y
Source: Herpes - July 21, 2022 Category: Infectious Diseases Authors: Tomoki Todo Yasushi Ino Hiroshi Ohtsu Junji Shibahara Minoru Tanaka Source Type: research
