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Endovascular treatment of acute tandem lesions in patients with mild anterior circulation stroke
Conclusions EVT for tandem lesions in patients with mild anterior circulation stroke appears to be feasible but may lead to increased rates of sICH. Further studies comparing endovascular with best medical treatment (BMT) especially investigating the risk of periprocedural hemorrhagic complications, are needed.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Meyer, L., Politi, M., Alexandrou, M., Roth, C., Kastrup, A., Mpotsaris, A., Hanning, U., Flottmann, F., Brekenfeld, C., Deb-Chatterji, M., Thomalla, G., Kniep, H., Faizy, T. D., Bechstein, M., Broocks, G., Herzberg, M., Feil, K., Kellert, L., Dorn, F., Z Tags: Ischemic stroke Source Type: research

P089/268 Safety and efficacy of the fourth-generation Acandis Acclino Flex Plus stent in managing complex intracranial aneurysms
ConclusionThe AFP stent demonstrated feasibility and favourable safety and efficacy in the treatment of complex aneurysms. These results support its clinical use and highlight the need for further studies to evaluate its performance in different aneurysm subsets and to determine its specific role in the endovascular treatment of aneurysms.Disclosure of InterestCK serves as consultants for Acandis GmbH (Pforzheim, Germany) and proctor for MicroVention Inc./Sequent Medical (Aliso Viejo, CA, USA). David Zopfs is on the speaker’s bureau of Philips (Amsterdam, the Netherlands) and lecturer for Amboss GmbH (Cologne, Germany).
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Goertz, L., Zopfs, D., Schönfeld, M., Schlamann, M., Kabbasch, C. Tags: 1.1 HAEMORRHAGIC - Aneurysms Source Type: research

P090/269 Comparative analysis between a second-generation (acandis acclino) and a first-generation (enterprise) stent system
ConclusionAdvanced stents offer reduced thromboembolic risk and comparable aneurysm occlusion to first-generation stents due to their flexible design and surface modification. These results support the clinical use of advanced stent systems, but further comparative studies are needed to conclusively evaluate the efficacy of stent-assisted coiling with the Acclino stent and other systems.Disclosure of InterestCK serves as consultants for Acandis GmbH (Pforzheim, Germany) and proctor for MicroVention Inc./Sequent Medical (Aliso Viejo, CA, USA). David Zopfs is on the speaker’s bureau of Philips (Amsterdam, the Netherlan...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Goertz, L., Zopfs, D., Schönfeld, M., Turowski, B., Schlamann, M., Kabbasch, C. Tags: 1.1 HAEMORRHAGIC - Aneurysms Source Type: research

P124/272 Initial encounter with a cutting-edge mobile head CT scanner (Somatom On.site) in a neuro-intensive care unit
ConclusionThe study demonstrates the clinical effectiveness of modern mobile CT scanners in neurointensive care units. The Somatom On.site provides sufficient image quality, saves time and supports timely decision making. The integration of mobile CT scanners in NICUs improves patient care and workflow. Prospective studies are needed to validate these findings and assess the long-term impact in NICUs and other units, such as stroke units.Disclosure of InterestCK serves as consultants for Acandis GmbH (Pforzheim, Germany) and proctor for MicroVention Inc./Sequent Medical (Aliso Viejo, CA, USA).
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Goertz, L., Al-Sewaidi, Y., Habib, M., Ranft, A., Kabbasch, C. Tags: 3.1 OTHER - Innovation Source Type: research

P151/175 Direct aspiration with EMBOVAC - first clinical experience and clot composition (results the "PERFECT study)
ConclusionThis is the first clinical evaluation of EMBOVAC. Direct aspiration with EMBOVAC as first line therapy resulted in high rates of reperfusion and favorable clinical outcomes. Clot composition analysis can aid in better understanding of the stroke etiology and means for effective clot removal.Disclosure of InterestAcandis (OJ, CL, JF); Microvention (GM, CC, JF); Stryker (GM, CC, JF); Medtronic (GM, CC, JF); Surge2surgery (BG); MIVI (CC); Phenox (CL, JF); Penumbra (CL, JF); GSK (AS); German Ministry of Science & Education and Economy & Innovation, EU, Hamburgische Investitions-/Förderbank, Philips, B...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Lobotesis, K., Jansen, O., Marnat, G., Gory, B., Nordmeyer, H., Eckert, B., Alessandro, P., Cognard, C., Loehr, C., Bracco, S., Schaefer, A., Macera, A., Fiehler, J., Doyle, K., Piano, M. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P152/178 Safety and efficiency of bridging i.v. thrombolysis in M2 occlusions: a propensity-score-matched registry cohort study
ConclusionIn M2-occlusions, MT+IVT was not associated with increased risk of sICH. Patients receiving MT+IVT had lower 90d-mRS and a lower increase in mRS pre-stroke to 90d. However, probability of functional independence and rates of successful recanalization were similar compared to matched controls.Disclosure of InterestHK has financial interest in Eppdata GmbH.GT received fees as consultant and lecturer from Acandis, Alexion, Amarin, Boehringer Ingelheim, Bayer, BMS/Pfizer, Daiichii Sankyo and Portola. He serves in the board of the TEA Stroke Study and of ESO.JF is consultant for Cerenovus, Medtronic, Microvention, Pen...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Kniep, H., Meyer, L., Broocks, G., Bechstein, M., Faizy, T., Winkelmeier, L., Brekenfeld, C., Flottmann, F., Paula Hanning, U. M., Thomalla, G., Fiehler, J., Gellissen, S. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P159/213 Early clinical surrogates for functional outcome after mechanical thrombectomy in M2 occlusions compared to M1 occlusions
Conclusion24h NIHSS was identified as best surrogate for long-term functional outcome after thrombectomy for patients with M1 and M2 occlusion, while optimal cut-offs to predict good and excellent outcome were 1 NIHSS-point higher in M2 occlusions compared to M1 occlusions.Disclosure of InterestHK has financial interest in Eppdata GmbH.GT received fees as consultant and lecturer from Acandis, Alexion, Amarin, Boehringer Ingelheim, Bayer, BMS/Pfizer, Daiichii Sankyo and Portola. He serves in the board of the TEA Stroke Study and of ESO.JF is consultant for Cerenovus, Medtronic, Microvention, Penumbra, Phenox, Roche, Stryker...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Kniep, H., Meyer, L., Broocks, G., Bechstein, M., Winkelmeier, L., Faizy, T., Brekenfeld, C., Flottmann, F., Paula Hanning, U. M., Thomalla, G., Fiehler, J., Gellissen, S. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P174/304 CGuard stent in emergent settings- is the dual-layer stent safe? A multicenter study
ConclusionIn this multicenter study, the use of CGuard for emergent carotid artery stenting, particularly in tandem occlusions, was safe and resulted in lower rates of in-stent occlusions.Disclosure of InterestThe authors stated explicitly that there are no conflicts of interest in connection with this abstract.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Zidan, M., Voss, Y. L., Wolf, M., Christiane, K. F., Paech, D., Radbruch, A., Nordmeyer, H., Dorn, F. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

O20/181 Early reperfusion or complete reperfusion TICI 3: determinants of improve outcome after first pass recanalization in mechanical thrombectomy
ConclusionOnly 13% of the FP-related improvement in functional outcome is explained by higher rates of complete recanalization, suggesting significant importance of early recanalization and low number of MT maneuvers. Results may improve the understanding of the importance of FP-reperfusion vs. early TICI=3 and may help to optimize MT treatment strategies.Disclosure of InterestHK has financial interest in Eppdata GmbH.GT received fees as consultant and lecturer from Acandis, Alexion, Amarin, Boehringer Ingelheim, Bayer, BMS/Pfizer, Daiichii Sankyo and Portola. He serves in the board of the TEA Stroke Study and of ESO.JF is...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Kniep, H., Meyer, L., Bechstein, M., Winkelmeier, L., Faizy, T., Brekenfeld, C., Flottmann, F., Paula Hanning, U. M., Thomalla, G., Fiehler, J., Gellissen, S. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

O-041 Primary results of the pRESET for occlusive stroke treatment (PROST) randomized clinical trial
Conclusions and RelevancePROST is the first randomized clinical trial aiming to compare a novel versus an established stent-retriever technology, establishing a new scientific benchmark for stroke device trials. In all primary & secondary endpoints and analysis, the pre-specified threshold of non-inferiority was met.(ClinicalTrials.gov: NCT03994822)Disclosures R. Hanel: 1; C; NIH, Interline Endowment, Microvention, Stryker, CNX, Balt. 2; C; Medtronic, Stryker, Cerenovus, Microvention, Phenox, Rapid Medical, Q’Apel. 4; C; InNeuroCo, Cerebrotech, eLum, Endostream, Three Rivers Medical Inc, Scientia, RisT, BlinkTBI,...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Hanel, R., Klisch, J., Möhlenbruch, M., Vollherbst, D., Ulfert, C., Bozorgchami, H., Samaniego, E., Liebeskind, D., Lobsien, D., Pielenz, D., Sauvageau, E., Aghaebrahim, A., Clark, W., Priest, R., Ortega-Gutierrez, S., Lopes, D., Billingsley, J., Tags: SNIS 20th annual meeting oral abstracts Source Type: research

E-007 CLEVER: clinical evaluation of WEB 0.017 device in intracranial aneurysms - final results for ruptured and unruptured aneurysm at 12 months
ConclusionThese results show good efficacy and safety results at 12 months month, and no WEB related mortality at 12 months. These data confirm the safety and efficacy of WEB 0.017 use in intracranial aneurysm treatment, unruptured as well as ruptured, and are consistent with the results published up to date.Disclosures L. Spelle: 1; C; Philips. 2; C; Microvention, Stryker, Medtronic, Balt, Phenox. C. Cognard: 2; C; Stryker, Medtronic, Mivi, Cerenovus, Microvention. I. Szikora: 2; C; Stryker, Cerenovus, Medtronic, Microvention, Brainomix. F. Wodarg: 2; C; Microvention, Stryker, Cerus Endovascular, Balt, Johnson & Johns...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Spelle, L., Cognard, C., Szikora, I., Wodarg, F., Costalat, V., Herbreteau, D., Fischer, S., Möhlenbruch, M., Papagiannaki, C., Klisch, J., Rautio, R., Berlis, A., Downer, J., Bester, M., Velasco, S., Liebig, T., Byrne, J., Pierot, L. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Clinical experience with the Bendit steerable microcatheter: a new paradigm for endovascular treatment
Conclusions Our initial clinical experience with the Bendit21 microcatheter demonstrates its usefulness in achieving technical success in patients with challenging neurovascular conditions.
Source: Journal of NeuroInterventional Surgery - July 14, 2023 Category: Neurosurgery Authors: Killer-Oberpfalzer, M., Chapot, R., Orion, D., Barr, J. D., Cabiri, O., Berenstein, A. Tags: Open access, New devices New devices and techniques Source Type: research

Mechanical thrombectomy is cost-effective versus medical management alone around Europe in patients with low ASPECTS
Conclusions MT is efficient versus MM alone for patients with low ASPECTS in eight countries across Europe. Patients with a large ischemic core could be treated with MT because it is both clinically beneficial and economically sustainable.
Source: Journal of NeuroInterventional Surgery - June 16, 2023 Category: Neurosurgery Authors: Moreu, M., Scarica, R., Perez-Garcia, C., Rosati, S., Lopez-Frias, A., Egido, J. A., Gomez-Escalonilla, C., Simal, P., Arrazola, J., Bocquet, A.-L., Barthe, T. Tags: Open access, Ischemic stroke Source Type: research

Carotid artery direct access for mechanical thrombectomy: the Carotid Artery Puncture Evaluation (CARE) study
Conclusion In this large multicentric study, DCP was scantly performed for vascular access to perform MT (0.39%) in patients with AIS-LVO and had a high rate of complications (18.5%). Our results provide arguments for not closing the cervical access by manual compression after MT.
Source: Journal of NeuroInterventional Surgery - November 14, 2022 Category: Neurosurgery Authors: Dumas, V., Kaesmacher, J., Ognard, J., Forestier, G., Dargazanli, C., Janot, K., Behme, D., Shotar, E., Chabert, E., Velasco, S., Bricout, N., Ben Hassen, W., Veunac, L., Geismar, M., Eugene, F., Detraz, L., Darcourt, J., L'Allinec, V., Eker, O. F., Conso Tags: Ischemic stroke Source Type: research

P67 REcanalization of distal cerebral Vessels In acute Stroke using APERIO(R) (REVISAR): first interim analysis
DiscussionOur interim analysis shows high recanalization rates with a good safety profile, thus contributing to perspectively prove efficacy of MT of small/peripheral vessel occlusions.ReferencesHTTPS://CLINICALTRIALS.GOV/CT2/SHOW/NCT04479020?COND=NCT04479020&DRAW=2&RANK=1 Do you have any conflict of interest to declare?: YesConflict of Interest StatementFD serves as a Proctor/Consultant for Cerenovus, Balt, Cerus Endovascular, Stryker and AcandisHN serves as a Proctor/Consultant for Acandis und Balt.
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Dorn, F., Nordmeyer, H. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

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