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Long ‐term use of proton pump inhibitors, dose–response relationship and associated risk of ischemic stroke and myocardial infarction
ConclusionUse of PPIs was associated with increased risks of first‐time ischemic stroke and MI, particularly amongst long‐term users and at high doses.
Source: Journal of Internal Medicine - November 7, 2017 Category: Internal Medicine Authors: T. S. G. Sehested, T. A. Gerds, E. L. Fosb øl, P. W. Hansen, M. G. Charlot, N. Carlson, M. A. Hlatky, C. Torp‐Pedersen, G. H. Gislason Tags: Original Article Source Type: research

Long ‐term use of Proton Pump Inhibitors, Dose‐response Relationship, and Associated Risk of Ischemic Stroke and Myocardial Infarction
ConclusionUse of PPIs was associated with increased risks of first‐time ischemic stroke and MI, particularly among long‐term users and at high doses.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - October 1, 2017 Category: Internal Medicine Authors: Thomas S. G. Sehested, Thomas A. Gerds, Emil L. Fosb øl, Peter W. Hansen, Mette G. Charlot, Nicholas Carlson, Mark A. Hlatky, Christian Torp‐Pedersen, Gunnar H. Gislason Tags: Original Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.
Source: Journal of Internal Medicine - September 21, 2017 Category: Internal Medicine Authors: L. Staerk, T. A. Gerds, G. Y. H. Lip, B. Ozenne, A. N. Bonde, M. Lamberts, E. L. Fosb øl, C. Torp‐Pedersen, G. H. Gislason, J. B. Olesen Tags: Original Article Source Type: research

Important factors affecting the choice of an oral anticoagulant may be missed in database studies
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 7, 2017 Category: Internal Medicine Authors: Emma Aarnio, Risto Huupponen, Maarit Jaana Korhonen Tags: Letter to the Editor Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban, and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban, and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 1, 2017 Category: Internal Medicine Authors: Laila Staerk, Thomas A Gerds, Gregory Y H Lip, Brice Ozenne, Anders N Bonde, Morten Lamberts, Emil L Fosb øl, Christian Torp‐Pedersen, Gunnar H Gislason, Jonas B Olesen Tags: Original Article Source Type: research