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Molecules, Vol. 27, Pages 6837: In Vitro Activity of Essential Oils Distilled from Colombian Plants against Candida auris and Other Candida Species with Different Antifungal Susceptibility Profiles
a-Arango Multi-drug resistant species such as Candida auris are a global health threat. This scenario has highlighted the need to search for antifungal alternatives. Essential oils (EOs), or some of their major compounds, could be a source of new antifungal molecules. The aim of this study was to evaluate the in vitro activity of EOs and some terpenes against C. auris and other Candida spp. The eleven EOs evaluated were obtained by hydro-distillation from different Colombian plants and the terpenes were purchased. EO chemical compositions were obtained by gas chromatography/mass spectrometry (GC/MS). Antifungal activit...
Source: Molecules - October 12, 2022 Category: Chemistry Authors: Carolina Zapata-Zapata Manuela Loaiza-Oliva Mar ía C. Martínez-Pabón Elena E. Stashenko Ana C. Mesa-Arango Tags: Article Source Type: research

Molecules, Vol. 25, Pages 5704: Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis
rera Leishmaniasis is a parasitic morbid/fatal disease caused by Leishmania protozoa. Twelve million people worldwide are appraised to be currently infected, including ca. two million infections each year, and 350 million people in 88 countries are at risk of becoming infected. In Colombia, cutaneous leishmaniasis (CL) is a public health problem in some tropical areas. Therapeutics is based on traditional antileishmanial drugs, but this practice has several drawbacks for patients. Thus, the search for new antileishmanial agents is a serious need, but the lack of adequately funded research programs on drug discovery has...
Source: Molecules - December 3, 2020 Category: Chemistry Authors: Jeysson S ánchez-Suárez Freddy A. Bernal Ericsson Coy-Barrera Tags: Review Source Type: research