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Connexin 43 mediated the angiogenesis of buyang huanwu decoction via vascular endothelial growth factor and angiopoietin-1 after ischemic stroke
Chin J Physiol. 2022 Mar-Apr;65(2):72-79. doi: 10.4103/cjp.cjp_94_21.ABSTRACTBuyang Huanwu decoction (BYHWD), a classical prescription for ischemic stroke, has been reported to promote angiogenesis after focal ischemia. However, the mechanisms of the contribution of BYHWD on angiogenesis are still unclear. Connexin 43 (Cx43) played important roles in the functions of neurogliovascular unit. Therefore, the aim of this study was to explore the potential role of Cx43 in angiogenesis of the ischemic brain after BYHWD treatment. Middle cerebral artery occlusion (MCAO) was used to establish the model of focal ischemia. BYHWD was...
Source: The Chinese Journal of Physiology - April 30, 2022 Category: Physiology Authors: Ying Zhou Ya-Xing Zhang Kai-Ling Yang Yu-Lian Liu Fang-Hua Wu Yu-Rong Gao Wei Liu Source Type: research

Effects of female sex hormones on the development of atherosclerosis
Chin J Physiol. 2020 Nov-Dec;63(6):256-262. doi: 10.4103/CJP.CJP_69_20.ABSTRACTAtherosclerosis and associated pathologies, such as coronary artery disease, peripheral vascular disease, and stroke, are still the leading cause of death in Western society. The impact of female sex hormones on cardiovascular diseases has been studied intensively with conflicting findings. The controversy is mainly due to the differences in groups sampling, animal models used, hormonal treatment regimens, and the data analyzed. In the present article, the results of in vitro and in vivo studies and clinical trials are under review.PMID:33380610...
Source: The Chinese Journal of Physiology - December 31, 2020 Category: Physiology Authors: Sung-Po Hsu Wen-Sen Lee Source Type: research

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