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Effects of Naodesheng tablets on amyloid beta-induced dysfunction: A traditional Chinese herbal formula with novel therapeutic potential in Alzheimer's disease revealed by systems pharmacology
In conclusion, this is the first study to provide a comprehensive systems pharmacology approach to elucidate the potential therapeutic mechanism of NDS tablets for AD treatment. We suggest that the protective effects of NDS in neurodegenerative conditions could be partly attributed to its role in improving synaptic plasticity and inhibiting neuroinflammation via NF-κB signaling pathway inhibition and cAMP/PKA/CREB signaling pathway activation.PMID:34328103 | DOI:10.1016/j.biopha.2021.111916
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 30, 2021 Category: Drugs & Pharmacology Authors: Baoyue Zhang Jun Zhao Pengfei Guo Zhe Wang Lvjie Xu Ailin Liu Guanhua Du Source Type: research

Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes
CONCLUSION: Compared with SVM and DT models, the RF model showed the best performance, especially when the ratio of the training set to test set is 8:2. Compared with single predictive indexes, the model constructed by combining physiochemical indexes with TCM indexes (i.e. the fused indexes) exhibited better predictive ability. In addition to common physicochemical indexes, some TCM indexes, such as wiry pulse, chest tightness, spontaneous perspiration, greasy tongue coating, can also improve diagnosis of MS.PMID:33588265 | DOI:10.1016/j.biopha.2021.111367
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 15, 2021 Category: Drugs & Pharmacology Authors: Shu-Jie Xia Bi-Zhen Gao Shui-Hua Wang David S Guttery Can-Dong Li Yu-Dong Zhang Source Type: research

Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes.
CONCLUSION: Compared with SVM and DT models, the RF model showed the best performance, especially when the ratio of the training set to test set is 8:2. Compared with single predictive indexes, the model constructed by combining physiochemical indexes with TCM indexes (i.e. the fused indexes) exhibited better predictive ability. In addition to common physicochemical indexes, some TCM indexes, such as wiry pulse, chest tightness, spontaneous perspiration, greasy tongue coating, can also improve diagnosis of MS. PMID: 33588265 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 12, 2021 Category: Drugs & Pharmacology Authors: Xia SJ, Gao BZ, Wang SH, Guttery DS, Li CD, Zhang YD Tags: Biomed Pharmacother Source Type: research