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Basal bodies bend in response to ciliary forces
Mol Biol Cell. 2022 Oct 26:mbcE22100468T. doi: 10.1091/mbc.E22-10-0468-T. Online ahead of print.ABSTRACTMotile cilia beat with an asymmetric waveform consisting of a power stroke that generates a propulsive force and a recovery stroke that returns the cilium back to the start. Cilia are anchored to the cell cortex by basal bodies (BBs) that are directly coupled to the ciliary doublet MTs. We find that, consistent with ciliary forces imposing on BBs, bending patterns in BB triplet MTs are responsive to ciliary beating. BB bending varies as environmental conditions change the ciliary waveform. Bending occurs where striated f...
Source: Mol Biol Cell - October 26, 2022 Category: Molecular Biology Authors: Anthony D Junker Louis G Woodhams Adam W J Soh Eileen T O'Toole Philip V Bayly Chad G Pearson Source Type: research