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Drug: Melatonin
Countries: Canada Health
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Total 60 results found since Jan 2013.
Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis
CONCLUSION: Our results indicate that melatonin supplementation does not improve postoperative sleep quality measured with the VAS compared with placebo in adult patients (GRADE: moderate).STUDY REGISTRATION: PROSPERO (CRD42020180167); registered 27 October 2022.PMID:36977935 | DOI:10.1007/s12630-023-02442-1
Source: Canadian Journal of Anaesthesia - March 28, 2023 Category: Anesthesiology Authors: Akito Tsukinaga Takahiro Mihara Teppei Takeshima Makoto Tomita Takahisa Goto Source Type: research
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats
This study aimed to investigate the protective effect of M against contrast-induced nephropathy (CIN) and its impact on the crosstalk between inflammasome, apoptosis, and autophagy in CIN. Male albino rats received M (10, 20, and 40 mg/kg/day, intraperitoneally) for 3 days. One hour after the last administration, rats were subjected to CIN induction (10 mg/kg indomethacin, double doses of l-NAME 10 mg/kg, i.v., and meglumine diatrizoate 60% 6 mL/kg, i.v.). CIN-induced kidney damage was evidenced through elevated kidney function biomarkers and induced renal histopathological changes. Pretreatment with M caused a significant...
Source: Canadian Journal of Physiology and Pharmacology - August 26, 2022 Category: Drugs & Pharmacology Authors: Marwa Gamal Al-Shawadfy Gellan Alaa Mohamed Kamel Adel R A Abd-Allah Source Type: research
The Assessment and Treatment of Sleep Abnormalities in Children and Adolescents with Autism Spectrum Disorder: A Review
DISCUSSION: Sleep disturbances in this population are common and include insomnia, parasomnias, circadian rhythm disorders, and sleep-related movement disorders. Multiple factors may contribute to the higher rates of sleep disturbances in persons with ASD. Unfortunately, there are not evidence-based guidelines specific for the management of these sleep disorders in this population. There is also a lack of controlled clinical studies. Nevertheless, assessment of sleep problems using both subjective and objective methods are recommended to develop an individualized approach. Behavioural interventions are preferred first line...
Source: Journal of the Canadian Academy of Child and Adolescent Psychiatry - February 8, 2021 Category: Psychiatry Authors: Mandeep Rana Sanjeev Kothare William DeBassio Source Type: research
