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Evaluation of platelet activity by multiple electrode impedance aggregometry in acute coronary syndromes: pilot study in a Brazilian tertiary-care public hospital.
This study suggested that the evaluation of PA in ACS using MEA may identify non-responders to ASA. Larger studies are necessary to define, in a public health scenario, the value of MEA in the management of ACS. PMID: 30652826 [PubMed - in process]
Source: Braz J Med Biol Res - January 10, 2019 Category: Research Authors: De Lorenzo A, Dutra M, Mattos MA, Rey HCV, Tibirica E Tags: Braz J Med Biol Res Source Type: research

Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients
AbstractAnticoagulant and antiplatelet drugs effectively prevent thrombotic events in patients with cardiovascular diseases, ischemic stroke, peripheral vascular diseases, and other thromboembolic diseases. However, genetic and non-genetic factors affect the response to antithrombotic therapy and can increase the risk of adverse events. This narrative review discusses pharmacogenomic studies on antithrombotic drugs commonly prescribed in Brazil. Multiple Brazilian studies assessed the impact of pharmacokinetic (PK) and pharmacodynamic (PD) gene variants on warfarin response. The reduced function allelesCYP2C9*2 andCYP2C9*3...
Source: Molecular Diagnosis and Therapy - August 6, 2021 Category: Molecular Biology Source Type: research