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Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery
J Control Release. 2022 Nov 10:S0168-3659(22)00739-8. doi: 10.1016/j.jconrel.2022.10.061. Online ahead of print.ABSTRACTWith the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have received enormous attention. However, due to the extreme instability and low intracellular gene expression of naked genes, specific vectors are required. Viral vectors are widely used attributed to their high transfection efficiency. However, due to the safety concerns of viral vectors, nanotechnology-based non-viral vectors have attrac...
Source: Cancer Control - November 13, 2022 Category: Cancer & Oncology Authors: Hezhi Wang Lu Qin Xin Zhang Jian Guan Shirui Mao Source Type: research

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs
J Control Release. 2022 Aug 10:S0168-3659(22)00514-4. doi: 10.1016/j.jconrel.2022.08.009. Online ahead of print.ABSTRACTSince the recent clinical approval of siRNA-based drugs and COVID-19 mRNA vaccines, the potential of RNA therapeutics for patient healthcare has become widely accepted. Lipid nanoparticles (LNPs) are currently the most advanced nanocarriers for RNA packaging and delivery. Nevertheless, the intracellular delivery efficiency of state-of-the-art LNPs remains relatively low and safety- and immunogenicity concerns with synthetic lipid components persist, altogether rationalizing the exploration of alternative ...
Source: Cancer Control - August 13, 2022 Category: Cancer & Oncology Authors: Bram Bogaert F élix Sauvage Roberta Guagliardo Cristina Muntean Van Phuc Nguyen Eline Pottie Mike Wels An-Katrien Minnaert Riet De Rycke Qiangbing Yang Dan Peer Niek Sanders Katrien Remaut Yannis M Paulus Christophe Stove Stefaan C De Smedt Koen Raemdonc Source Type: research