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Total 532 results found since Jan 2013.
CHAC1 exacerbates arsenite cytotoxicity by lowering intracellular glutathione levels
J Toxicol Sci. 2023;48(9):487-494. doi: 10.2131/jts.48.487.ABSTRACTWe here examined whether CHAC1 is implicated in arsenite (As(III))-induced cytotoxicity in HaCaT cells. We found that HaCaT cells in which the intracellular GSH levels were elevated by transfection with CHAC1 siRNA showed decreased sensitivity to As(III) compared to the control cells. Treatment with BSO (an inhibitor of GSH biosynthesis) abolished the decrease in sensitivity to As(III), suggesting that an increase in intracellular GSH levels was involved in the decrease in sensitivity to As(III) due to the decrease in the levels of CHAC1 expression. When we...
Source: Journal of Toxicological Sciences - September 4, 2023 Category: Toxicology Authors: Daigo Sumi Hiroki Taguchi Kumiko Takeuchi Hitomi Fujishiro Source Type: research
Gossypol enhances the efficacy of sorafenib by trigging autophagy and apoptosis in metastatic lung cancer cells: An upshot of Chou-Talalay combination index process
In conclusion combination of gossypol and sorafenib shows synergistic increase in the cytotoxic effect by promoting autophagy and apoptosis.PMID:37611852 | DOI:10.1016/j.tiv.2023.105666
Source: Toxicology in Vitro - August 23, 2023 Category: Toxicology Authors: Yusuf Hussain Abha Meena Rohit Anthony Sinha Source Type: research
