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Genetic predisposition to ocular surface disorders and opportunities for gene-based therapies
Ocul Surf. 2023 May 14:S1542-0124(23)00045-9. doi: 10.1016/j.jtos.2023.05.003. Online ahead of print.ABSTRACTThe ocular surface, comprised of the corneal and conjunctival epithelium, innervation system, immune components, and tear-film apparatus, plays a key role in ocular integrity as well as comfort and vision. Gene defects may result in congenital ocular or systemic disorders with prominent ocular surface involvement. Examples include epithelial corneal dystrophies, aniridia, ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome, xeroderma pigmentosum (XP), and hereditary sensory and autonomic neuropathy. In additio...
Source: The Ocular Surface - May 16, 2023 Category: Opthalmology Authors: Danial Roshandel Farbod Semnani Amirmasoud Rayati Damavandi Ali Masoudi Alireza Baradaran-Rafii Stephanie L Watson William H Morgan Samuel McLenachan Source Type: research

Recovering vision in corneal epithelial stem cell deficient eyes
A healthy corneal epithelium is essential for vision. Patients often present with conditions that impact negatively on the integrity of the ocular surface and these can include minor abrasions, allergies, keratitis, dry eye, ocular herpes, and pterygium to name just a few. Treatment regimens for these conditions often involve a pharmacological approach. However, when the epithelium is defective owing to limbal stem cell deficiency, treatment is notoriously difficult. Corneal epithelial stem cells are widely believed to reside in the basal epithelium at the limbus [1,2].
Source: Contact Lens and Anterior Eye - April 28, 2019 Category: Opthalmology Authors: Kiranjit K. Bains, Hideki Fukuoka, Chie Sotozono, Andrew J. Quantock Source Type: research

Corneal Epithelial Wound Healing and Bactericidal Effect of Conditioned Medium From Human Uterine Cervical Stem Cells Cornea
Conclusions. Treatment with CM-hUCESCs improved wound healing of alkali-injured corneas and showed a strong bactericidal effect on CLs. Patients using CLs and suffering from dry eye, allergies induced by commercial solutions, or small corneal injuries could benefit from this treatment.
Source: Investigative Ophthalmology - February 11, 2015 Category: Opthalmology Authors: Bermudez, M. A., Sendon-Lago, J., Eiro, N., Trevino, M., Gonzalez, F., Yebra-Pimentel, E., Giraldez, M. J., Macia, M., Lamelas, M. L., Saa, J., Vizoso, F., Perez-Fernandez, R. Tags: Cornea Source Type: research

Demographic and clinical profile of vernal keratoconjunctivitis at a tertiary eye care center in India
Conclusion: Clinical pattern of VKC seen in the tropical climate of India is essentially similar to that seen in other tropical countries. Few distinct features that we noted represent chronic perennial disease, low association with atopy, and higher propensity for disease and treatment-related complications.
Source: Indian Journal of Ophthalmology - October 8, 2013 Category: Opthalmology Authors: Ujwala S SabooManish JainJagadesh C ReddyVirender S Sangwan Source Type: research