Filtered By:
Specialty: Environmental Health
This page shows you your search results in order of date. This is page number 3.
Order by Relevance | Date
Total 205 results found since Jan 2013.
PM < sub > 2.5 < /sub > increases mouse blood pressure by activating toll-like receptor 3
CONCLUSIONS: PM2.5 exposure increased BP via TLR3 activation and impaired vascular function.PMID:35247710 | DOI:10.1016/j.ecoenv.2022.113368
Source: Ecotoxicology and Environmental Safety - March 5, 2022 Category: Environmental Health Authors: Jinna Zhang Rucheng Chen Guoqing Zhang Yixuan Wang Jing Peng Renjie Hu Ran Li Weijia Gu Lu Zhang Qinghua Sun Cuiqing Liu Source Type: research
Gestational exposure to BDE-209 induces placental injury via the endoplasmic reticulum stress-mediated PERK/ATF4/CHOP signaling pathway
We examined the impacts of gestational exposure to BDE-209, the most abundant PBDE conger detected in human samples, on placental structure and function, and its model of action in vivo and in vitro. Pregnant mice were exposed to 0, 2, 20, 200 mg/kg/day of BDE-209 by gavages from gestational day (GD) 0 to GD18. Results showed that gestational BDE-209 exposure significantly reduced placental weight, impaired placental vascular development and induced placental cell apoptosis. In addition, gestational BDE-209 exposure impaired placental transport and endocrine function as demonstrated by markedly downregulated expression of ...
Source: Ecotoxicology and Environmental Safety - February 19, 2022 Category: Environmental Health Authors: Yan Zhao Kechen Fan Yan Zhu Yongbo Zhao Jing Cai Liping Jin Source Type: research
GSDMD-miR-223-NLRP3 axis involved in B(a)P-induced inflammatory injury of alveolar epithelial cells
In conclusion, GSDMD may regulate NLRP3 inflammasome through miR-223, which is involved in B(a)P induced inflammatory damage in A549 cells.PMID:35144130 | DOI:10.1016/j.ecoenv.2022.113286
Source: Ecotoxicology and Environmental Safety - February 10, 2022 Category: Environmental Health Authors: Xiangbing Kong Min Gao Yitong Liu Peng Zhang Mengyuan Li Pengwei Ma Pingping Shang Wei Wang Hong Liu Qiao Zhang Feifei Feng Source Type: research
siRNA@superparamagnetic iron oxide nanoparticles attenuate physiological toxicity of DEHP by suppressing autophagy pathway activities in Caenorhabditis elegans
Ecotoxicol Environ Saf. 2021 Dec 13;229:113083. doi: 10.1016/j.ecoenv.2021.113083. Online ahead of print.ABSTRACTBis(2-ethylhexyl)ortho-phthalate (DEHP) is a widely used plasticizer in polyvinyl chloride materials. Considering its widespread application, it has become a major environmental pollutant and can cause endocrine, reproductive system, and gastrointestinal disorders. Herein we aimed to elucidate the mechanisms via which DEHP causes cytotoxicity in Caenorhabditis elegans and assess whether siRNA@superparamagnetic iron oxide nanoparticles (SPIONs) can attenuate this effect. On exposing C. elegans to 10 μM DEHP, its...
Source: Ecotoxicology and Environmental Safety - December 16, 2021 Category: Environmental Health Authors: Yongyi Huang Xiling Du Te Liu Qiang Liu Source Type: research
Long non-coding RNA SNHG1 promotes fibroblast-to-myofibroblast transition during the development of pulmonary fibrosis induced by silica particles exposure
In this study, a mouse model of pulmonary fibrosis via intratracheal instillation of silica particles was established, and the differential expression of lnc-SNHG1 and miR-326 in lung tissues and TGF-β1-treated fibroblasts was detected by the qRT-PCR method. Short interfering RNA (siRNA) and plasmid were designed for knockdown or overexpression of lnc-SNHG1 in fibroblasts. MiRNA simulant was designed for overexpression of miR-326 in vivo and in vitro. Dual-luciferase reporter system, immunofluorescence, western blot, wound healing and transwell assay were performed to investigate the function and the underlying mechanisms...
Source: Ecotoxicology and Environmental Safety - November 6, 2021 Category: Environmental Health Authors: Qiuyun Wu Biyang Jiao Wenwen Gui Qianyi Zhang Feng Wang Lei Han Source Type: research
High-fat diet exacerbated BDE-209-induced hepatocyte apoptosis via intensifying the transfer of Ca < sup > 2+ < /sup > from endoplasmic reticulum to mitochondria
This study aimed to evaluate the hepatotoxicity of BDE-209 in lean and high-fat diet (HFD)-treated obese mice and elucidate the underlying mechanisms. Firstly, the increasing levels of triacylglycerol and proinflammatory factors in the liver and ALT and AST in serum demonstrated the hepatic damage caused by BDE-209 and further exacerbated by HFD. Tunel image revealed that BDE-209 induced more severe hepatocyte apoptosis with the assistant of HFD. Next, the mechanism analysis showed that the pro-apoptotic action of BDE-209 was in an endoplasmic reticulum (ER)/Ca2+ flux/mitochondria-dependent manner, concluded from the impai...
Source: Environmental Pollution - October 8, 2021 Category: Environmental Health Authors: Sunni Chen Siyan Che Shiqi Li Jin Wan Zheng Ruan Source Type: research
ALKBH5 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating PTEN expression in an m6A-dependent manner
In this study, human bronchial epithelial BEAS-2B cells were transformed by exposing to 2 μM of cadmium for 20 weeks to investigate the role of m6A in cadmium carcinogenesis. We found the level of m6A in mRNA was significantly decreased in cadmium-transformed BEAS-2B cells, and this change was regulated by m6A demethylase ALKBH5. ALKBH5 was significantly upregulated in the middle and late stages of cell transformation at week 8, 12, 16 and 20. Knockdown of ALKBH5 in cadmium-transformed cells alleviated cell proliferation, migration, invasion, and anchorage-independent growth, but co-transfection with ALKBH5 siRNA and PTEN...
Source: Ecotoxicology and Environmental Safety - August 26, 2021 Category: Environmental Health Authors: Luyao Li Mei Zhou Biyun Chen Qin Wang Shuya Pan Yaxuan Hou Jiamin Xia Xue Zhou Source Type: research
The epigenetic regulator BRD4 is involved in cadmium-triggered inflammatory response in rat kidney
Ecotoxicol Environ Saf. 2021 Aug 13;224:112620. doi: 10.1016/j.ecoenv.2021.112620. Online ahead of print.ABSTRACTCadmium (Cd) has been described as a potential inflammatory inducer, while increasing evidence shows that inappropriate inflammation is a contributing factor to kidney injury. Hence, research on Cd-triggered inflammatory response is of great significance for elucidating the mechanism of Cd-induced nephrotoxicity. Bromodomain-containing 4 (BRD4) is an important epigenetic regulator involved in the development of many inflammatory diseases, but its regulatory roles in Cd-triggered inflammatory response remain to b...
Source: Ecotoxicology and Environmental Safety - August 15, 2021 Category: Environmental Health Authors: Zhonggui Gong Gang Liu Wenjing Liu Hui Zou Ruilong Song Hongyan Zhao Yan Yuan Jianhong Gu Jianchun Bian Jiaqiao Zhu Zongping Liu Source Type: research
