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Total 883 results found since Jan 2013.
A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats
This study aims to investigate the protective role of ADTM in MIR injury and clarify the potential role of PAFR. We measured the effects of ADTM on MIR injury in rats in vivo and hypoxia re-oxygenation (HR) injury in neonatal rat ventricular myocytes (NRVMs) in vitro. The results show that ADTM can significantly improve the IR-induced decline in heart function as increasing EF and FS, and restore the decreased cardiac hemodynamic parameters (LVSP, ± dp/dt max) and increased the level of LVEDP, decrease the infarct size of damaged myocardium and lactate dehydrogenase (LDH) activity in serum. Additionally, ADTM inhibits car...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Jinghao Wang Kai Fan Cong He Qingyang Wang Qianhui Zhang Wei Huang Source Type: research
Immune checkpoint molecules are regulated by transforming growth factor (TGF)- < em > β < /em > 1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma
Int J Med Sci. 2021 Apr 22;18(12):2466-2479. doi: 10.7150/ijms.54239. eCollection 2021.ABSTRACTHepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a high mortality rate. Epithelial-to-mesenchymal transition (EMT) confers cancer cells with immune evasive ability by modulating the expression of immune checkpoints in many cancers. Thus, the aim of our study is to examine the interplay between EMT and immune checkpoint molecules in HCC. A reversible EMT model was utilised with transforming growth factor (TGF)-β1 as an EMT inducer for HCC cell lines Hep3B and PLC/PRF/5. HCC cells were treated wi...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Ritu Shrestha Kim R Bridle Darrell H G Crawford Aparna Jayachandran Source Type: research
A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats
This study aims to investigate the protective role of ADTM in MIR injury and clarify the potential role of PAFR. We measured the effects of ADTM on MIR injury in rats in vivo and hypoxia re-oxygenation (HR) injury in neonatal rat ventricular myocytes (NRVMs) in vitro. The results show that ADTM can significantly improve the IR-induced decline in heart function as increasing EF and FS, and restore the decreased cardiac hemodynamic parameters (LVSP, ± dp/dt max) and increased the level of LVEDP, decrease the infarct size of damaged myocardium and lactate dehydrogenase (LDH) activity in serum. Additionally, ADTM inhibits car...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Jinghao Wang Kai Fan Cong He Qingyang Wang Qianhui Zhang Wei Huang Source Type: research
Immune checkpoint molecules are regulated by transforming growth factor (TGF)- < em > β < /em > 1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma
Int J Med Sci. 2021 Apr 22;18(12):2466-2479. doi: 10.7150/ijms.54239. eCollection 2021.ABSTRACTHepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a high mortality rate. Epithelial-to-mesenchymal transition (EMT) confers cancer cells with immune evasive ability by modulating the expression of immune checkpoints in many cancers. Thus, the aim of our study is to examine the interplay between EMT and immune checkpoint molecules in HCC. A reversible EMT model was utilised with transforming growth factor (TGF)-β1 as an EMT inducer for HCC cell lines Hep3B and PLC/PRF/5. HCC cells were treated wi...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Ritu Shrestha Kim R Bridle Darrell H G Crawford Aparna Jayachandran Source Type: research
A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats
This study aims to investigate the protective role of ADTM in MIR injury and clarify the potential role of PAFR. We measured the effects of ADTM on MIR injury in rats in vivo and hypoxia re-oxygenation (HR) injury in neonatal rat ventricular myocytes (NRVMs) in vitro. The results show that ADTM can significantly improve the IR-induced decline in heart function as increasing EF and FS, and restore the decreased cardiac hemodynamic parameters (LVSP, ± dp/dt max) and increased the level of LVEDP, decrease the infarct size of damaged myocardium and lactate dehydrogenase (LDH) activity in serum. Additionally, ADTM inhibits car...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Jinghao Wang Kai Fan Cong He Qingyang Wang Qianhui Zhang Wei Huang Source Type: research
Immune checkpoint molecules are regulated by transforming growth factor (TGF)- < em > β < /em > 1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma
Int J Med Sci. 2021 Apr 22;18(12):2466-2479. doi: 10.7150/ijms.54239. eCollection 2021.ABSTRACTHepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a high mortality rate. Epithelial-to-mesenchymal transition (EMT) confers cancer cells with immune evasive ability by modulating the expression of immune checkpoints in many cancers. Thus, the aim of our study is to examine the interplay between EMT and immune checkpoint molecules in HCC. A reversible EMT model was utilised with transforming growth factor (TGF)-β1 as an EMT inducer for HCC cell lines Hep3B and PLC/PRF/5. HCC cells were treated wi...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Ritu Shrestha Kim R Bridle Darrell H G Crawford Aparna Jayachandran Source Type: research
A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats
This study aims to investigate the protective role of ADTM in MIR injury and clarify the potential role of PAFR. We measured the effects of ADTM on MIR injury in rats in vivo and hypoxia re-oxygenation (HR) injury in neonatal rat ventricular myocytes (NRVMs) in vitro. The results show that ADTM can significantly improve the IR-induced decline in heart function as increasing EF and FS, and restore the decreased cardiac hemodynamic parameters (LVSP, ± dp/dt max) and increased the level of LVEDP, decrease the infarct size of damaged myocardium and lactate dehydrogenase (LDH) activity in serum. Additionally, ADTM inhibits car...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Jinghao Wang Kai Fan Cong He Qingyang Wang Qianhui Zhang Wei Huang Source Type: research
Immune checkpoint molecules are regulated by transforming growth factor (TGF)- < em > β < /em > 1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma
Int J Med Sci. 2021 Apr 22;18(12):2466-2479. doi: 10.7150/ijms.54239. eCollection 2021.ABSTRACTHepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a high mortality rate. Epithelial-to-mesenchymal transition (EMT) confers cancer cells with immune evasive ability by modulating the expression of immune checkpoints in many cancers. Thus, the aim of our study is to examine the interplay between EMT and immune checkpoint molecules in HCC. A reversible EMT model was utilised with transforming growth factor (TGF)-β1 as an EMT inducer for HCC cell lines Hep3B and PLC/PRF/5. HCC cells were treated wi...
Source: International Journal of Medical Sciences - June 9, 2021 Category: Biomedical Science Authors: Ritu Shrestha Kim R Bridle Darrell H G Crawford Aparna Jayachandran Source Type: research
